KAMAGATE Soualio, KOKORE Angoua Baudouin, OUATTARA Howele, BLEYERE Nahounou Mathieu, YAPO Angoue Paul
Abstract: In treatment of the HIV/AIDS, the tri-therapy prescribes to the patients is generally made up of two therapeutic classes which are 2NRTIs+1NNRTI and 2NRTIs + 1IP.To evaluate the effect of these various therapeutic classes (2NRTIs+1IP and 2NRTIs+1NNRTI) on the biological monitoring parameters, a study was conducted on people infected by HIV. To do this, blood samples were taken from 45 subjects at the beginning of treatment up to 12 months. The results of our investigations showed that the 2NRTIs+1NNRTI therapeutic class was the most used during treatment with 84.44 %, 80 % and 75.56 % respectively at M0, M06 and M12. At the erythrocyte level, anemia was very common among patients under the therapeutic class 2NRTIs+1IP, which with a rate of 28.6 % at M0 increased to 33.3 % at M06 and 45.5 % at M12.In the same view, a significant increase of 27 % in the prevalence of CD4 in the sixth month compared to the average rate at the beginning (respectively 28.6 % and 55.6 %) was observed. On the other hand, from M0 to M12, this rate dropped without a significant difference of 1.1 %. Concerning the other parameters the majority of the subjects being under the two therapeutic classes had normal rates. This study shows that the different therapeutic classes had an effect on the biological parameters of our subjects.
Keywords: Therapeutic classes, HIV, biological monitoring parameters, Abidjan (Cote d'Ivoire)