Y. C. Kaushik, Abhijeet Kumar, Shankar Chilumula
Abstract: A prospective study was carried out in 100 patients of Acute Myocardial Infarction. Patients with normal uric acid level served as control and the others with elevated uric acid level constituted the study subjects. The complications and short term outcomes were compared in the two groups. The proportion of hyperuricemics in the study population was 59 %. Out of the 8 patients who succumbed to death following an acute myocardial infarction, all of them were hyperuricemic at presentation. This establishes a strong significant association between elevated serum uric acid levels and mortality rates in acute coronary syndrome. In our study out of 100 STEMI patients 70 male and 30 female patients with a mean age of 54.85 ± 12.78 years 90 % of patients had hypertriglyceridemia, 51 % had elevated serum uric acid (>7.0 mg/dl). Mean serum uric acid level was 7.15±2.38. Overall in-hospital mortality was 8 %; in all of whom serum uric acid levels were >7mg/dl (p=0.02). We concluded that serum uric acid levels were elevated in patients with acute myocardial infarction. There is a strong correlation between serum uric acid levels at the time of admission and in-hospital and short-term mortality in patients with acute myocardial infarction. Patients with elevated SUA levels had higher Killip class in STEMI, higher mortality rates and major adverse cardiovascular outcomes. Patients with elevated serum uric acid had lower ejection fraction. Uric acid may be considered as a reliable, non-invasive, easily available and cheap independent prognostic marker in predicting the severity of myocardial infarction along with short term outcome.
Keywords: Serum uric acid SUA, Myocardial Infarction MI, Hypertriglyceridemia, BMI