International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


Downloads: 112

Research Paper | Chemistry | India | Volume 3 Issue 9, September 2014


Hydrogen-Bond Parameters and Lipophilicity of Hydroxamic Acids: Use in Drug Design

Piyush Kumar Thakur [3] | Sandhya Patre [2] | Rama Pande


Abstract: Hydroxamic acid provides central functionality in a number of metalloproteinase inhibitors because of its ability to strongly coordinate with metal ions and as such has high relevance for the development of new pharmaceuticals. Hydroxamic acids, the naturally occurring and synthetic products, generally have low toxicities and are of interest for many therapeutic applications. The lipophilicity of a series of hydroxamic acids have been measured experimentally between chloroform-water, octanol-water and chloroform-octanol systems, by the shake-flask method. Measured lipophilicities of compounds obtained are in the range 2.516 to 2.358. The measured Hydrogen Bond Donor (HBD) and Hydrogen Bond Acceptor (HBA) strengths are in the range 0.6239 to 0.7098 and 1.9288 to 2.8292, respectively. This study is designed to assess the correlation between the lipophilicity of the compounds and their biological activity. The results show that these molecules have better chances to arrive at receptor sites. In QSAR where physico-chemical parameters of drugs are correlated with biological activities, lipophilicity plays a major role. A knowledge of these parameters will help in designing the better drug delivery system and more accurately marked pharmaceuticals and pesticides.


Keywords: Hydroxamic acid, partition coefficient, hydrogenbonds, lipophilicity


Edition: Volume 3 Issue 9, September 2014,


Pages: 1545 - 1548


How to Download this Article?

You Need to Register Your Email Address Before You Can Download the Article PDF


How to Cite this Article?

Piyush Kumar Thakur, Sandhya Patre, Rama Pande, "Hydrogen-Bond Parameters and Lipophilicity of Hydroxamic Acids: Use in Drug Design", International Journal of Science and Research (IJSR), Volume 3 Issue 9, September 2014, pp. 1545-1548, https://www.ijsr.net/get_abstract.php?paper_id=SEP14447

Similar Articles with Keyword 'Hydroxamic acid'

Downloads: 2

Research Paper, Chemistry, Sudan, Volume 10 Issue 7, July 2021

Pages: 617 - 620

Spectrophotometric Study of Stability Constants of Fe (III), Co (II) and Cu (II) Complexes of Salicylhydroxamic Acid at Room Temperatures

Leena Salah Ibrahim [2] | Elmugdad Ahmed Ali [4] | Mohammed Sulieman Ali [2]

Share this Article

Downloads: 2

Research Paper, Chemistry, Sudan, Volume 10 Issue 7, July 2021

Pages: 621 - 626

Preparation and Characterization of Salicylhydroxamic acid and its Complexes with Iron (III), Cobalt (II) and Manganese (II)

Leena Salah Ibrahim [2] | Elmugdad Ahmed Ali [4] | Mohammed Sulieman Ali [2]

Share this Article
Top