Diuretic and Salidiuretics Activity of an Aqueous Extract of Leafy Branches of Mimosa invisa Mart. ex. Colla (Fabaceae) in Rats

Irie Bi Jean Severin | Abo Kouakou Jean Claude ^[2] | Kahou Bi Gohi Parfait

Abstract: In this study, the aqueous extract of Mimosa invisa (Miv), at doses ranging from 5 to 20 mg / kg b. w. , causes a dose-dependent and significant increase (p < 0.001) of the volume of urinary excretion measured during 24 hours and at dose of 20 mg / kg b. w, a significant decrease (p < 0.01) of time of the first micturition (TFM) in rats treated. These effects of Miv suggest that this extract is a diuretic. In addition, Miv significantly increases urinary excretion of Na+, K+ and Cl- (p <0.01). However, the urinary ratio Na +/K + does not vary significantly in the presence of Miv, which is in favor of a more pronounced action of this extract on the renal tubules. In addition, the effects of Miv on diuresis and the TFM are similar to those of hydrochlorothiazide, furosemide and spirolactone at doses of 20 mg / kg b. w. The salidiuretic effects of Miv are also similar to those of hydrochlorothiazide and furosemide, but differs from that of the spirolactone which to him decreases (p < 0, 05) the urinary excretion of K. In addition, unlike Miv, spironolactone has an increase (p < 0.01) of the urinary ratio Na+ / K+. This study shows that the extract of Mimosa invisa is a diuretic whose effects are similar to those of furosemide and hydrochlorothiazide. These diuretic properties of Miv justify the use of Mimosa invisa (Fabaceae) in traditional medicine to treat arterial hypertension.

Keywords: Mimosa invisa, diuretic and salidiuretic, furosemide, hydrochlorothiazide, spirolactone

Edition: Volume 5 Issue 4, April 2016,

Pages: 1475 - 1479