Krishna Murthy V, Venkata Madhav M, Anjaneya Prasad V, Pradeep Babu
Abstract: Dyslipidemia is an abnormal lipid metabolism leads to elevation in serum lipids results in hyperlipidemias, particularly hypercholesterolemia and hypertriglyceredemia or combined, which intern predisposes atherosclerosis and then triggers micro or macro vascular complications like cardiovascular and cerebro vascular system. The purpose of this case - control study was to correlate atherogenic lipid abnormalities in sub clinical hypothyroidism to non sub clinical hypothyroid patients. This study was done at the Department of Biochemistry, DR. PSIMS & RF foundation Chinaoutpally, A.P. India between Jan 2012 to Dec 2012. 100 patients (50 Sub Clinical Hypothyroidism, 50 age and sex matched controls) above 18 years of age were included in the study. The mean TSH was Sub Clinical Hypothyroidism was 9.96 + 3.57 and in controls was 2.26 + 1.45 (p = 0.05). The mean Cholesterol levels were 218.1+35.75 and 158.95+26.45 in Sub Clinical Hypothyroidism and control groups respectively. The mean Triglyceride levels were 172.85+81.25 and 131.05+60.65 in Sub Clinical Hypothyroidism and control groups respectively Mean HDL - Cholesterol levels of males was lower than females in Sub Clinical Hypothyroid groups (p Value <0.05). The study concludes that Dyslipidemia is more common in sub clinical hypothyroidism and it enhances the risk of premature atherosclerosis causing cardiovascular and cerebro vascular complications.
Keywords: Hypothyroidism, serum cholesterol, lipids, thyrotropin