Gajanan Mogal, Vaibhav Changadiya
Abstract: The present work aimed to develop nanoemulsion of mefenamic acid for improving its efficacy, stability, and permeability for the treatment of rheumatoid arthritis. A nanoemulsion was prepared using aqueous titration method composed of capmul oil as the oil phase, tween 60 as surfactant and Polyethylene glycol 400 as cosurfactant and evaluated. The aqueous phase titration method was employed for constructing the existing zone of nanoemulsion in pseudoternary phase diagrams representing three axes of the aqueous phase, oil, and mixture of surfactant and cosurfactant. The prepared nanoemulsions were placed in tightly closed glass vials and stored at ambient temperature. These drug-loaded formulations were subjected to physical stability tests [centrifugation stress (5000 rpm, 30 min), heating cooling stress (0 and 45C, eight cycles) and freeze-thawing stress (-21 and 25 C, 48 h) ], appearance, percent transmittance, refractive index, Electrical conductivity. In conclusion, nanoemulsion of mefenamic acid was developed to a satisfactory level in terms of physical stability tests, appearance, percent transmittance, refractive index, Electrical conductivity, lower surfactant concentration. The present study endorsed nanoemulsion of mefenamic acid to be a promising choice over conventional formulations for the treatment of rheumatoid arthritis.
Keywords: Mefenamic acid, rheumatoid arthritis, nanoemulsion, capmul oil