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Review Papers | Pharmacology Science | India | Volume 8 Issue 7, July 2019

Repercussion and Ways to Overwhelm the Drug Failure in Clinical Trials

Kajal Andotra | Raibarinder Singh ^[2]

Abstract: Drug development is a very complex process. It is extremely difficult to find best drug which will increases the success rate of drug in market. Drug faces many challenges during its development. It is not necessary that all scientific inventions translate into a better outcome. The success rate of drug is falling day by day. The main reasons behind drug failure are efficacy, safety and commercial concerns of the drug. Lack of commitment by the companies also leads to high failure rate of drug. Drug failure ultimately impacts human life style as well as their emotional health and has financial impact due to arise of AD6R and unaffordable high price of drug in market. Patent life is an important aspect to sustain a viable business. Shareholders always do one’s best to extend the time period of patent expiry for their own profit. Pharmaceutical organizations must adopt best ways to overcome the rate of drug failure.5R framework enhances the success rate of trials by identifying right target, right patient, right safety, right tissue and right commercial potential for the betterment of emerging future of pharmaceutical industry. . Before the initiation of research, it must be important for all pharmaceutical industries to aware about the drug’s history either it shows any ADR in past. Recognition of susceptible drug is mandatory for all pharmaceutical companies which will not lead into mishappening in clinical trials. Inventors or shareholders needs to focus on research process in depth rather than their own profit.

Keywords: ADR, NME, FDA, CSDD, 5R

Edition: Volume 8 Issue 7, July 2019,

Pages: 1696 - 1699

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