Rupali B. Kamthane, Dr. Aamer Quazi, T. Vidhate
Abstract: Smoking is injurious to health. Smoking cessation is the process of discontinuing smoking. Nicotine present in tobacco is addictive & makes the process of quitting very prolonged & complex. Nicotine causes pulmonary diseases, lung cancer & heart diseases. Quitting smoking drastically reduces risk of dying from tobacco-related diseases. The current established procedures for smoking cessation have wide variety of side effects & in comparison buccal thin films are better alternative due to negligible side effects & fast discharge of nicotine, which also avoids first pass metabolism. So the aim of the study was to develop the films for potential delivery of Nicotine by the buccal mucosa of Adult patients. Films were prepared using hydroxypropyl methyl cellulose (HPMC K-15), hydroxypropyl methyl cellulose (HPMC E-5), glycerin as plasticizer, sucrose as sweetener, citric acid as saliva stimulating agent and water as solvent. Nicotine is freely soluble in alcohol & miscible in Water. Hence alcohol is used as a co-solvent to enhance the solubility of nicotine in water. The films were prepared by using solvent casting method & then evaluated. Buccal film is useful for improving the patient compliance due to ease of use.
Keywords: Nicotine, Smoking cessation, FTIR, Drug release