Dr. Minakshi Kumari, Dr. Prof. Bela Rose Ekka, Dr. Prof. Santosh Kumar
Abstract: Background: The prevalence of infertility is estimated between 12-14 %. Hormonal disorders of female reproductive system are comprised of a number of problems resulting from aberrant dysfunction of hypothalamic- pituitary-ovarian axis. Materials and Methods: The study was conducted on 50 women (age group 2140 years) in Biochemistry Department of RIMS, Ranchi between March 2017- March 2018.Hormonal profile were done by enhanced chemiluminescent microparticle immunoassay method on ABOTT ARCHITECT i1000SR IMMUNOASSAY analyzer.50 fertile woman with similar age were enrolled as the controls. Results: There was a positive correlation between serum TSH and prolactin levels in the infertile subjects. Hyperprolactinemia was depicted in 57 % of the infertile women while it was 7 % in the control group. The infertile women with hypothyroidism had significantly higher prolactin levels when compared to the controls. Conclusion: Hyperprolactinemia with thyroid dysfunction may be a major contributory hormonal factor in female infertility patients and estimation of prolactin, FT3, FT4, and TSH should be included in the workup for patients with female infertility.
Keywords: Prolactin, thyroid profile, infertility