Abstract: Background: Non-alcoholic fatty liver disease (NAFLD) is commonly associated with type 2 diabetes mellitus (DM). We carried out a prospective case-control study showing correlation of NAFLD in patients with type 2 DM and its connection with Insulin Resistance. Materials and Methods: Total 97 patient out of 100 patients of Type 2 DM attending Muzaffarnagar medical college and hospital completed the study and were evaluated using SPSS software version 12. Abdominal ultrasound was performed to establish the presence of fatty liver. For assessment of Insulin Resistance, Homeostasis Model Assistant Insulin Resistance (HOMAIR) was calculated. A probability value of P < 0.05 was considered statistically significant. Results: The study group of 100 was divided into a NAFLD group of 45 and a nonNAFLD group of 55 with NAFLD as 45 %. The NAFLD subgroup had excessive obesity which was measured by BMI and central obesity was measured by waist circumference and waist hip ratio, higher HbA1c and higher triglyceride levels. HOMAIR for Insulin Resistance was significantly higher in NAFLD group than Non NAFLD group (P value 0.03). Conclusion: The frequency of NAFLD is high in patients of Type 2 DM. Insulin resistance correspond with the presence of NAFLD among T2DM patients.
Keywords: Insulin Resistance, non-alcoholic fatty liver disease, type 2 diabetes mellitus