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Research Paper | Medical Surgical | India | Volume 8 Issue 12, December 2019
A Comparative Study of Effect of Etomidate, Propofol and Etomidate Plus Propofol Induction on Hemodynamic Response to Endotracheal Intubation: A Prospective Randomized Controlled Study
Dr. B. Vishnu Mahesh Babu | Dr. B. Anil Sarath Chandra
Abstract: Aim: The primary objective of this current study was to compare the efficacy of three different anaesthesia induction approach (Inj. Etomidate, Inj. Propofol, and Inj. Etomidate plus Inj. propofol) in maintaining hemodynamic stability during induction followed by endotracheal intubation in patients undergoing elective surgeries. Material and methods: Total 90 patients, aged 16 to 65 years of both sex and ASA physical status I or II scheduled for elective surgeries under general anaesthesia were taken for this present study. After taking both written and informed consent, the patients were randomly placed into three groups. Group E with Inj. Etomidate (0.3 mg/kg) intravenously, Group P induced with Inj. Propofol (2.5 mg/kg) intravenously, and Group PE with Inj. Etomidate (0.2 mg/kg) plus Inj. Propofol (1.5 mg/kg) intravenously. Patient's Heart rate (HR), Systolic blood pressure (SBP), Diastolic blood pressure (DBP), Mean arterial blood pressure (MAP), and Saturation percentage of Oxygen (SPO2) were noted at different time interval. 2 Results: In all the study groups Heart rate (HR) decreases after induction, and it is more in group P when compared to group E and PE. Among all the three groups MAP decreases after induction, and it was more in group P than group E and PE. MAP increases significantly at 1 min after intubation in all the three study groups, but this increase is not sustained and returned to baseline in group E and PE. Conclusion: Hemodynamic stability is better with the combination of etomidate plus propofol than that of etomidate alone at 1 min after intubation, even though etomidate is equally stable at other points of time. The combination has proved to be significantly better than the administration of etomidate or propofol individually.
Keywords: Etomidate, Propofol, Heart rate, Mean arterial pressure, Laryngoscopy
Edition: Volume 8 Issue 12, December 2019,
Pages: 799 - 803
Similar Articles with Keyword 'Etomidate'
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Research Paper, Medical Surgical, India, Volume 7 Issue 4, April 2018
Pages: 1217 - 1222A Comparative Evaluation of Propofol, Etomidate and Admixture of Propofol - Etomidate for Induction During General Anaesthesia
Dr. Sunita Alawa | Dr. Avtar Singh Yadav | Dr. Subhash Agrawal | Dr. Sudhakar Dwivedi
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Research Paper, Medical Surgical, India, Volume 6 Issue 11, November 2017
Pages: 481 - 486Comparison of Haemodynamic Profile of Thiopentone and Etomidatein to Pressor to Laryngoscopy and Intubation
Sreemayi Chodagam | Aruna V Chandak | Deepjit Bhuyan