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Research Paper | Immunology | India | Volume 8 Issue 11, November 2019

Mass Spectrometry - The Future of In Vitro Diagnostics (IVDs)

Raghavendra Krishnappa ^[3] | Natesha B Khadrinarasimhaiah ^[2]

Abstract: In Vitro Diagnostics should be swift and accurate to ensure patients do not seek unnecessary treatments, delay in needed treatments or become exposed to inappropriate therapies. IVD laboratories are in urgent need of transition from conventional instruments to modern analytical instruments which gives accurate data in the fastest and easiest way. To address this concern, Mass Spectrometry is the perfect solution as it is the gold standard for accuracy. Liquid chromatography (LC), standalone or by coupling with tandem mass spectrometry (LC-MS/MS) and Gas chromatography with tandem mass spectrometry (GC-MS/MS) is particularly powerful for high-resolution separation, identification and quantitation of hormones, amino acids, fatty acids, proteins and peptides [Table-02] even at very low levels of expression. MS analytical instrument vendors are providing affordable benchtop platforms offering high sensitivity, low detection limits and high specificity, leading to better data than alternative testing methods to support clinicians with confident results.

Keywords: IVD or IVDs In Vitro Diagnostic/s, MS Mass Spectrometry, LC-MS/MS - Liquid chromatography with tandem mass spectrometry, GC-MS/MS - Gas chromatography with tandem mass spectrometry, FP False Positive, FN False Negative, MALDI-TOF - Matrix Assisted Laser Desorption Ionization Time of Flight

Edition: Volume 8 Issue 11, November 2019,

Pages: 1793 - 1799

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