Daklallah Ahmed Almalki
Abstract: Histologically, thioacetamide (TAA) is a well-known toxic compound that induces liver cirrhosis and other metabolic disorders which may lead to serious complications. The potential of Anisotes trisulcus as a hepatoprotective herb was evaluated in experimentally-induced, TAA-mediated liver cirrhosis in mice model. Healthy male mice were employed in the current study and randomly assigned into four groups. The first group was the normal control, while the second group were exposed to TAA by intraperitoneal injection. Mice of the third group orally received A. trisulcus leaves extract alongside the TAA intraperitoneal injection. The fourth group was only supplemented with A. trisulcus leaves extract. After three months of experimental treatments, histopathological examination of liver tissue sections from TAA-treated mice with revealed shown increase in the deposition of extracellular collagen and fibrosis. Alterations of tissue architecture and large fibrous septae were observed as a result of collagen condensation around the lobules. Obtained result of the current study showed that the leave extract of A. trisulcus possess hepatoprotective effect against TAA-induced liver cirrhosis by preventing the histopathological alterations. Supplementation of A. trisulcus aqueous extract may confer antioxidant effect and could be an excellent supportive component in the treatment of liver cirrhosis.
Keywords: Intraperitoneal, Saudi Arabia, Liver injury, Histopathological examination