Dr. Ishrat Jahan, Dr. C. V. Kulkarni
Abstract: The p53 gene is a tumour suppressor gene. The significance of p53 expression is that p53 mutation is correlate with chemo-resistance and transformation to more aggressive disease in infiltrating duct carcinoma breast. In addition, the expression of p53 has been closely correlated with clinicopathological findings like lymph node positivity, recurrence of disease, distal metastasis, and poor outcome. The expression of p53 was studied in 100 cases of invasive ductal carcinoma of the breast, received in department of histopathology in MYH hospital Indore M.P. Detection of p53 done by HRP polymer method if immunohistochemistry. It was found that p53 was expressed in 86 % of all the study cases. Expression of other markers like ER/PR, Her2/neu and ki67 also performed on same specimen. Furthermore, its expression was significantly correlated with tumor grade, lymph node status and with other IHC marker for breast. Knowledge of the p53 status may be valuable in making clinical decisions regarding diagnosis, prognosis and therapy.
Keywords: Breast cancer, p53 expression, clinical prognostic factor