Downloading: Spectrometric Method Development for the Estimation of Cidofovir Dihydrate in Bulk and Pharmaceutical Formulation
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064



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Spectrometric Method Development for the Estimation of Cidofovir Dihydrate in Bulk and Pharmaceutical Formulation

S. D. Jadhav, A. R. Sable, S. U. Budhwant, N.S. Choudhari

Abstract: A simple, specific and rapid difference spectroscopic method has been developed for the estimation of Cidofovir dihydrate in bulk and Pharmaceutical formulation. The proposed method was carried out by measuring the difference absorbance of Cidofovir dihydrate in two different conditions containing three different forms of drug generated by neutral (solvent), acidic (solvent) and basic (solvent) medium. The measurements of difference absorbance were carried out at 270 nm for two different conditions. The calibration curves were linear in the concentration range of 10- 60g/ml. The proposed method was validated as per ICH validation guideline Q2 (R1) for accuracy, robustness, LOD, LOQ etc. The method was found to be accurate, precise, robust and sensitive hence it can be applied in routine analysis of Cidofovir dihydrate in bulk and Pharmaceutical formulation in its quality control.

Keywords: Cidofovir, Infra-red Spectroscopy, Potassium Bromide, Acetone



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