Formulation Development and In-Vitro Evaluation of Microsponges Gel Loaded with Anti Fungal Drug

Kandula Swarna | Thummala Uday Kumar

Abstract: Objective of this research work was to formulate and evaluate antifungal drug Miconozoleloadedmicrosponges gel form for sustained topical drug delivery. In this study, efforts has been made to prepare microsponges containing Miconazole by quasi-emulsion solvent diffusion method using different polymers like Eudragit RL100, Eudragit L100 and Ethyl cellulose. Optimization of best suitable polymer was determined based on product production yield, loading efficiency and drug content of drug loaded microsponges. Prepared topical microsponges gels were evaluated for pH, viscosity measurement, spread ability, estimation of content of drug, drug release studies. Best formulation has to be chosen, depending on the criteria such as maximum drug release from the microspongesgel. Formulation with drug and polymerratio1: 5 shows good sustained drug release up to 24 hours. Optimizedformulation was studied for rate release kinetics.

Keywords: Miconozole, Microsponges, Eudragit RL 100 and Quasi emulsion solvent diffusion method

Edition: Volume 8 Issue 6, June 2019,

Pages: 1367 - 1371