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Research Paper | Pharmaceutical Science | India | Volume 8 Issue 6, June 2019
Formulation and Evaluation of Floating Matrix Tablet of Riboflavin
Chandresh Raghuwanshi | Dr. Shikha Agarwal
Abstract: Floating matrix tablets of Riboflavin were developed to prolong gastric residence time, leading to sustained action of the drug. The single layertablets prepared by wet granulation compression technique using polymers hydroxypropylmethyl cellulose (METHOCEL), Carbopol and other standard excipients. Calcium carbonate was incorporated as a gas-generating agent. The effect of polymers, diluents (lactose & microcrystalline cellulose) on drug release profile, floating properties were investigated. The tablets were evaluated for thickness, hardness, friability, swelling index, mucoadhesion and in vitro drug release. Polymer with lower viscosity (hydroxyl propyl methyl cellulose K4M) was found to be beneficial than higher viscosity polymer (Carbopol) in improving the release properties of gastric floating drug delivery system. Incorporation of Carbopol in formulation helped in maintaining buoyancy of system. The formulation F4 was optimized based on floating time (3±0.057 min).
Keywords: Carbopol, Gas generating agent, Floating matrix system, Hydroxyl propyl methyl cellulose, Riboflavin
Edition: Volume 8 Issue 6, June 2019,
Pages: 1887 - 1891
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Research Paper, Pharmaceutical Science, India, Volume 12 Issue 12, December 2023
Pages: 277 - 281Formulation and Evaluation of Fexofenadine Nanoparticles Loaded in Gel
Ayesha Farhath Fatima | Ayesha Begum [3] | Mariyam Yaseen [2]
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Research Paper, Pharmaceutical Science, India, Volume 12 Issue 12, December 2023
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Mayuri Patil | Vaishnavi Salokhe | Pranali Jadhav | Satyajit Lad | Suraj Jadhav