K. Kavitha, Dr. R. A. M. Jainaf Nachiya
Abstract: The objective of present study is to formulate and in-vitro evaluation of non-effervescent of Furosemide gastroretentive floating tablets, and to interpret the in-vitro dissolution studies. The purpose of this research was introduce low cost of the therapy, ease of administration lead to high levels of patient compliance and prepare floating drug delivery (FDD) as non effervescent tablets (Furosemide) containing furosemide by direct compression method. This present study were used various polymers such as HPMC K4M, K100M and K15M at various proportions. Among all the formulations, F6 formulations were produced desire drug released up to 9th hour, findings were satisfactory and flow property. The finding of tablets parameters for flow properties such as (angle of repose, compressibility index, Hausner ratio, bulk density and tapped density were performed as an indication of good flow properties also prepared tablets were determined floating parameters like swelling index and invitro buvyancy test and estimated the mechanism of the drug release rate kinetics of the dosage form, the data were supported with zero-order, first order, Higuchi, and Korsmeyer-Peppas release model. Among all the formulation, formulations [F6] were followed Higuchi model.
Keywords: gastroretentive floating tablets, HPMC, swelling index, buvyancy test