Nguyen Xuan Thanh
Abstract: Bacterial cellulose (BC) can be produced by bacteria in culture media. BC contain some superior properties such as a nano-sized ultrafine fiber network, high water-holding capacity and ease of fabrication into a desired shape, which are capable of drug absorbing to form a prolonged release therapy to improve drug bioavailability. BCs were prepared and evaluated for drug carrier using curcumin and famotidine as model drugs. Acetobacter xylinum was successfully isolated from Kombucha. BC was produced by Acetobacter xylinum in the standard medium (SM), coconut medium (CM) and rice medium (RM). The BC-CM, and BC-RM have characteristics the same as the BC-SM, and BC can be fabricated with the desired thickness and diameter in culture media. BCs were absorbed the famotidine in optimal condition with no difference in famotidine loading (20mg) and entrapment efficiency (89-90 %). The amount of loaded curcumin and entrapment efficacy of BC-SM and BC-CM were higher than them of BC-RM. Investigation of the BC structure by SEM showed that the cellulose fibers of BC-SM and BC-CM have a stable structure, without modifications in structure when loading under optimal condition. The results indicate the potential for using BC-SM and BC-CM to produce the drug carrier.
Keywords: Bacterial cellulose BC, curcumin, drug carrier, famotidine, kombucha