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Comparative Studies | Medical Surgical | India | Volume 8 Issue 1, January 2019
Application of Tranexamic Acid in Total Knee Replacement Surgeries
Sandra Everest | Radhesh Hegde [6]
Abstract: Total knee replacement surgeries are associated with perioperative blood cell transfusions and a higher rate of postoperative morbidity and mortality. Perioperative antifibrinolytic therapy is recommended to reduce blood loss. This study was conducted on a total of 30 subjects randomly divided into two groups of 15 patients each. The first group (Group T) received Tranexamic acid (15 mg/kg of body weight mixed in 100 ml normal saline). The second group (Group P) received a bolus of an equivalent volume of placebo (normal saline), 10 minutes before the deflation of the pneumatic tourniquet respectively. Our study showed that Group P lost almost five times more blood during the recovery phase and twice the volume of Group T in the surgical ward. Based on the results of the present study, we concluded that use of Tranexamic Acid significantly reduces blood loss caused by TKR performed with a tourniquet
Keywords: Tranexamic acid, blood loss, anemia, coagulation
Edition: Volume 8 Issue 1, January 2019,
Pages: 1392 - 1394
Similar Articles with Keyword 'Tranexamic acid'
Downloads: 115
Research Paper, Medical Surgical, India, Volume 6 Issue 11, November 2017
Pages: 1845 - 1846Effect of Tranexamic Acid on Blood Loss in Percutaneous Nephrolithotomy
Prakash J.V.S [2] | Balaji A.R [2]
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Research Paper, Medical Surgical, India, Volume 4 Issue 6, June 2015
Pages: 1027 - 1029The Prophylactic Role of Tranexamic Acid to Reduce Blood Loss during Radical Surgery: A Prospective Study
Dr. Anil Kumar M.S | Dr. Raxith Sringeri R | Dr. Harish S | Dr. Sindhuri K [2] | Dr. Sai Sarath Chandra