International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


Downloads: 142

Research Paper | Biochemistry | Nigeria | Volume 7 Issue 1, January 2018


Identification of the Active Ingredients in Methanolic Leaf Extract of Aspilia africana (Pers.) C.D. Adams and their Effects on Ibuprofen Induced Ulcer Model in Wistar Rats

SC Okereke | UO Arunsi | AC Ngwogu | JO Onyike | SC Chukwudoruo


Abstract: Peptic ulcer is one of the most dreadful diseases in the world today. However, the present study was investigated to identify the active ingredients in the methanolic leaf extract of Aspilia africana and their possible effects on Ibuprofen induced ulcer model in Wistar rats using standard analytical methods. The GC-MS spectral analysis revealed thirty three (33) active ingredients with 9, 12, 15-Octadecatrienoic acid, methyl-ester (z, z, z) -, stigmasterol, hexadecanoic acid, methylester (z) -, Methyl linolelaidate, n-Hexadecanoic acid, squalene, phytol and vitamin E possessing important pharmacological and cytoprotective functions. The oral acute (LD50) toxicity study divulged that the extract did not cause mortality to any of the experimental animals even at the highest dose of 5000mg/kg. Other studies disclosed that the induction of ulcerogenesis by ibuprofen led to alterations in the mucosal membrane and this was evidenced by severe distortions in gastric contents, serum concentrations of blood glucose, antioxidant enzymes, lipid peroxidation marker, hepatocellular enzymes, renal function and haematological indexes. Pretreatment with the natural antidote (A. africana leaf extract) remediated this imbalance significantly more than a standard antiulcer drug (omeprazole). From these observations, we conclude that the methanolic leaf extract of A. africana offers more promising gastroprotection than omeprazole and due to low toxicity, it should be incorporated in traditional medicine for the management and treatment of peptic ulcer disease.


Keywords: Aspilia africana, active ingredients, NSAIDs, antiulcerogenicity, GC-MS


Edition: Volume 7 Issue 1, January 2018,


Pages: 310 - 319


How to Download this Article?

You Need to Register Your Email Address Before You Can Download the Article PDF


How to Cite this Article?

SC Okereke, UO Arunsi, AC Ngwogu, JO Onyike, SC Chukwudoruo, "Identification of the Active Ingredients in Methanolic Leaf Extract of Aspilia africana (Pers.) C.D. Adams and their Effects on Ibuprofen Induced Ulcer Model in Wistar Rats", International Journal of Science and Research (IJSR), Volume 7 Issue 1, January 2018, pp. 310-319, https://www.ijsr.net/get_abstract.php?paper_id=ART20179220

Similar Articles with Keyword 'active'

Downloads: 0

Research Paper, Biochemistry, Gabon, Volume 10 Issue 12, December 2021

Pages: 1234 - 1240

Evaluation of the Antioxidant Activity of Aqueous and Methanolic Extracts of Various Organs of Alchornea cordifolia by Scavenging the Radical Ion ABTS?+

N'Negue ep Mezui-Mbeng M.-A. | Ella Ndong J. G. | Lendoye E. | Nguema Edzang R. W. | Mackosso A. H. K

Share this Article

Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper, Biochemistry, India, Volume 11 Issue 9, September 2022

Pages: 922 - 924

Phytochemical Characterization of Leaf, Stem and Root Extract of Andrographis Paniculata

Keerti Samdariya | O. P. Rai

Share this Article
Top