International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


Downloads: 158

Research Paper | Oncology Science | Egypt | Volume 6 Issue 2, February 2017


Stem Cell Markers Epithelial Cell Adhesion Molecule (EpCAM) & Cluster of Differentiation (CD44) Expression in Colon Cancer Patients in Relation to Prognosis and Survival

Lobna A. Abdelaziz [2] | Ola A. Megahed [2] | Ola A. Harb [2] | Loay M. Gertallah | Ahmed M. Sallam [2]


Abstract: Background - Worldwide, Colon cancer is the third & the second most common cancer in males & female respectively. Its recurrence, therapy resistance and metastasis remain causes of poor prognosis. The relationship between cancer stem cell (CSC) behavior and chemo-resistance to chemotherapy in patients with colon cancer is a recent point of researches that has taken attention. Identification of CSCs needed specific cell surface markers. CD44 had been the most frequently researched marker for colon CSCs. EpCAM is a cell surface molecule involved in cell to cell adhesion that is expressed in many epithelial carcinomas. Aim of the work - was to evaluate CSC markers EPCAM & CD44 expressions in colon carcinoma correlating their expressions with clinicopathological parameters and patients outcome. Patients and Methods The clinic-pathological correlations between CD44 & EpCAM expressions were assessed in specimens of colon carcinoma embedded in paraffin blocks and were taken from 50 patients, which we followed up for survival and prognosis. Results- CD 44 & EpCam positive expression was significantly correlated with the grade, stage, presence of lymph node, lymphovascular invasion (p<0.001 for all), distant metastases (p<0.001 & = 0.016 respectively), T stage (p= 0.027 & 0.003) respectively. Mean PFS was 27.41.5, median PFS was not reached.3-y PFS was 56 % which was significant with each one of CD44 & EpCam (P<0.001 for both). While, Mean OS was 30.51.2, median OS was not reached, 3-yOS was 64 % with significant association with each one of the markers (P=0.002 for both). Conclusion- we concluded that both CD44 & EpCam positive expressions would be useful poor prognostic markers for colon carcinoma patients.


Keywords: Stem cell markers, CD44, EpCam, colon cancer, survival


Edition: Volume 6 Issue 2, February 2017,


Pages: 994 - 1005


How to Download this Article?

You Need to Register Your Email Address Before You Can Download the Article PDF


How to Cite this Article?

Lobna A. Abdelaziz, Ola A. Megahed, Ola A. Harb, Loay M. Gertallah, Ahmed M. Sallam, "Stem Cell Markers Epithelial Cell Adhesion Molecule (EpCAM) & Cluster of Differentiation (CD44) Expression in Colon Cancer Patients in Relation to Prognosis and Survival", International Journal of Science and Research (IJSR), Volume 6 Issue 2, February 2017, pp. 994-1005, https://www.ijsr.net/get_abstract.php?paper_id=ART2017780

Similar Articles with Keyword 'survival'

Downloads: 1

Case Studies, Oncology Science, India, Volume 11 Issue 4, April 2022

Pages: 1037 - 1041

Metachronous Lower GI Malignancies in Head and Neck Squamous Cell Carcinoma: A Case Report and Literature Review

Dr. Avinash Poojari | Dr. Rohini Khurana

Share this Article

Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Case Studies, Oncology Science, India, Volume 12 Issue 7, July 2023

Pages: 2108 - 2110

Paediatric Giant Cell Glioblastoma: A Rare Case Study and Review of Treatment Strategies

Dr. Nallabothula Sai Kiran | Dr. Nadakuduru Gnana Harsha | Dr. M. Ramakrishna [2] | Dr. Sudha Rani | Dr. K. Krishna [3] | Dr. Uma Maheshwari Devi

Share this Article
Top