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Research Paper | Mechanics Science | Iraq | Volume 6 Issue 9, September 2017
Comparative Study of Sevelamer Carbonate and Calcium Carbonate on Fibroblast Growth Factor-23 and Parathyroid Hormone in Hemodialysis Iraqi Patients
Ali Abdulmajid Dyab Allawi, Zainab Taha Mohammed Jaddoa, Omar Farooq Al Azzawi, Sajida Hussein Ismail
Fibroblast growth factor-23, play an important role in atherosclerosis, endothelial dysfunction and vascular calcification.Sevelamer can improve vascular calcification, serum uric acid, low-density lipoprotein -cholesterol and Fibroblast growth factor-23.Aim of study Assesment the effect of sevelamer as phosphate binder against calcium carbonate on Fibroblast growth factor-23. Methods A prospective open- labelled study that included patients on hemodialysis. A total of 72 patients were screened, only 53 patients completed the 10 week period. Adults patients with serum phosphate as >5.5 mg/dl were included. There were Group1 Includes 28 patients (19 males and 9 females receiving sevelamer carbonate (Renvela) tablet. Group 2 Include 25patients (17 male and 8 female) receiving calcium carbonate tablet. Level of serum calcium, phosphorus, albumin, at pre wash, baseline and every 5 weeks, meanwhile the Level Low-density lipoprotein, Fibroblast growth factor23, and parathyroid hormone were measured at baseline and after 10 weeks.ResultsSerum phosphorus was significantly reduced after 10 weeks with both sevelamer carbonate -22.4 % and calcium carbonate -23.5 %. Serum parathyroid was significantly reduced in both groups. Only group 1 was associated with significant reduction in low-density lipoprotein cholesterol by 26.4 % from base line, significant reduction in Fibroblast growth factor-23 level by -31.2 % and significant decrease in Calcium phosphate product -29.5 %.Significant rise in the serum calcium in group 2 patients (14.34 %). ConclusionSevelamer superior to calcium-based binders in reducing hypercalcemia and Calcium phosphate product which decrease intimal calcification of dialysis patient arteries, and favorable reduction in Fibroblast growth factor 23, and low-density lipoprotein cholesterol in dialysis patients.
Keywords: Sevelamer carbonate, Calcium carbonate, Fibroblast growth factor-23
Edition: Volume 6 Issue 9, September 2017
Pages: 1407 - 1411
How to Cite this Article?
Ali Abdulmajid Dyab Allawi, Zainab Taha Mohammed Jaddoa, Omar Farooq Al Azzawi, Sajida Hussein Ismail, "Comparative Study of Sevelamer Carbonate and Calcium Carbonate on Fibroblast Growth Factor-23 and Parathyroid Hormone in Hemodialysis Iraqi Patients", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20176700, Volume 6 Issue 9, September 2017, 1407 - 1411
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