International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


Downloads: 115 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper | Biochemistry | Iraq | Volume 6 Issue 9, September 2017


Concentration of R-spondin 2 in the Follicular Fluid is Correlated with Oocyte Number and Metaphase II Oocytes in Iraqi Women Undergo ICSI

Enas Jasim Kadim | Estabraq Al Wasiti [2] | Hala Abdul Qader [2]


Abstract: Background R-spondin2 is a protein expressed in the ovary at specific stages of follicular development the effect of R-spondin-2 on the follicles mimic the effect of FSH but differs in the intracellular mechanism in signal transduction cascades some studies suggested R-spondin2 agonist could provide a new treatment regimen for infertile women with low responses to tradional ovarian stimulating therapy. Objective to evaluate the concentration of R-spondin2 in the follicular and serum of women who undergo ICSI and to find if there is any correlation of the concentration of R-spondin2 with oocytes number Metaphase II (MII) number. Methods follicular fluid and serum were collected from 45 women age ranged 18-42 years who undergo ICSI in the day of oocyte retrieval, the number of oocytes and MII were counted, the concentration of R-spondin2 was measured using ELISA kit. Results the concentration of R -spondin 2 in the follicular fluid is correlated with oocytes number and MII number and there was no difference in the SEM between pregnant and non-pregnant women. Conclusion data of the present study show that R-spondin-2 has a direct positive effect on maturation of oocytes that provide basis for future studies about the possibility of inclusion of R-spondin2 analog in treatment of FSH irresponsive patients.


Keywords: R-spondin2, follicle development, ICSI


Edition: Volume 6 Issue 9, September 2017,


Pages: 65 - 68


How to Download this Article?

You Need to Register Your Email Address Before You Can Download the Article PDF


How to Cite this Article?

Enas Jasim Kadim, Estabraq Al Wasiti, Hala Abdul Qader, "Concentration of R-spondin 2 in the Follicular Fluid is Correlated with Oocyte Number and Metaphase II Oocytes in Iraqi Women Undergo ICSI", International Journal of Science and Research (IJSR), Volume 6 Issue 9, September 2017, pp. 65-68, https://www.ijsr.net/get_abstract.php?paper_id=ART20176210

Top