International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Fully Refereed | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064


Downloads: 124

Research Paper | Biomedical Sciences | Indonesia | Volume 6 Issue 7, July 2017


Effect of High Dose Vitamin C on Folliculogenesis of Female Adult Wistar Rats (Rattus norvegicus)

L. Yenny Armayanti | A. Aristo Parut


Abstract: Vitamin C is a Natural antioxidants that generally have beneficial health effect and marketed as a dietary suplement, partly because of its antioxidant properties. If the intakes of vitamin C are very high, ascorbic acid remains in its oxidized form as dehydroascorbic acid and an ascorbate free radical, which may cause damage of macromolecules and cells. The aims of this study were to investigate the effect of administration of high dose vitamin C on folliculogenesis of female adult Wistar Rats (Rattus norvegicus). A total of twenty eight female Wistar rats were randomly divided into 4 group of 7 rats each. Group 1 as control was given distilled water 2 ml/week, group 2, 3, 4 as treatment groups were given Vitamin C 5, 25 mg/week (subfisiologis), 8 mg/week (fisiologis), 17, 5 mg/week (suprafisiologis) respectively. The number of secondary follicle and follicle de Graaf was count by Hematoxyclin Eosin Staining. The result showed a decrease of the number of secondary follicle and follicle de Graaf in group 4. Group 4 had lower number of of secondary follicle and follicle de Graaf compared with all treatment groups. There was no significant different betwen the number of follicle in group 1 with group 2 and 3 (p>0, 05), but there were a significant different in group 1 with group 4 (p


Keywords: Vitamin C, Secondary Follicle, Follicle de Graaf


Edition: Volume 6 Issue 7, July 2017,


Pages: 182 - 185


How to Download this Article?

You Need to Register Your Email Address Before You Can Download the Article PDF


How to Cite this Article?

L. Yenny Armayanti, A. Aristo Parut, "Effect of High Dose Vitamin C on Folliculogenesis of Female Adult Wistar Rats (Rattus norvegicus)", International Journal of Science and Research (IJSR), Volume 6 Issue 7, July 2017, pp. 182-185, https://www.ijsr.net/get_abstract.php?paper_id=ART20174979

Similar Articles with Keyword 'Vitamin C'

Downloads: 54

Masters Thesis, Biomedical Sciences, Indonesia, Volume 10 Issue 1, January 2021

Pages: 804 - 808

Oral Administration of Tamarillo Seeds (Solanum Betaceum Cav.) Ethanol Extract Inhibited the Decrease of Leydig Cells and Testosterone Levels in Male Wistar Rats (Rattus Novergicus) Exposed to Cigarette Smoke

Adinda Sarah | Wimpie I. Pangkahila [3] | A.A.A.N. Susraini [5]

Share this Article

Downloads: 85

M.Tech / M.E / PhD Thesis, Biomedical Sciences, Indonesia, Volume 9 Issue 8, August 2020

Pages: 1082 - 1085

The Application of 5.4% Lime Peel Etanol Extract Cream (Citrus aurantifolia) inhibited the Increase of Matrix Metalloproteinase-1 Expression and the Decreased Amount of Collagen in Guinea Pigs (Cavia Porcellus) that were exposed to Ultraviolet B Rays

Dwi Ariyanti

Share this Article
Top