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International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
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Review Papers | Immunology | India | Volume 6 Issue 4, April 2017

Role of Mannose Binding Lectin and their associated Srine Protease in innate immunity

Pankaj Kumar Patel, Bavita Kohli, Krishnan Hajela

Mannose binding Lectin (MBL) is a key pattern recognition receptor molecule, found in invertebrates to higher vertebrates, MBL initiates various immune and immunomodulatory responses on binding with the pathogen associated molecular patterns (PAMPs). MBL recognizes a wide variety of viruses, bacteria, protozoa, fungi and cell debris opsonizing and clearing them either by opsonophagocytosis or activating complement pathway through MASP-1/2 mediated cleavage of complement components C4 and C2, thus generating the C3 convertase C4bC2b. A new insight on the responses, their mechanism and role of MBL associated serine proteases are discussed in the review.

Keywords: Mannose binding Lectin, Complement pathway, Pentraxin, Lectin pathway, MASP

Edition: Volume 6 Issue 4, April 2017

Pages: 620 - 625

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How to Cite this Article?

Pankaj Kumar Patel, Bavita Kohli, Krishnan Hajela, "Role of Mannose Binding Lectin and their associated Srine Protease in innate immunity", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=ART20172170, Volume 6 Issue 4, April 2017, 620 - 625



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