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Research Paper | Chemistry | Iraq | Volume 6 Issue 3, March 2017
Synthesis and Characterization of Some New Schiff Bases Derived from 7-hydroxy-4-methyl Coumarin
Abdel-Amir M. Fenjan | Inas S. Mahdi | Selvana Adwar Yousif [2]
Abstract: Coumarins induce researchers for further developments in organic synthesis because of their pharmaceutical and biological activities. The current research aimed to synthesize new Schiff bases derived from 7-hydroxy-4-methyl-coumarin containing amide, hydrazine carbothioamide, ethylidene moieties. Compound (1) (7-hydroxy-4-methyl coumarin) was converted into quinolin-2 (H) -one derivative (2) by the reaction with acetamide. Reaction of derivative (2) with thiosemicarbazide in ethanol leads to the synthesize of (7-hydroxy-4-methyl-2-oxoquinolin-1 (2H) -yl) ethylidene) hydrazinecarbothioamide derivative (3). Schiff bases (4-6) are prepared through the reaction of (3) with one of aldehydes or ketone. New coumarin derivatives are characterized by their physical properties and various spectral analysis like FTIR, 1HNMR, GC-Ms spectra and micro elemental analysis (C. H. N. S) technique for some of them.
Keywords: Synthesis, Coumarin, Quinolin, Schiff bases
Edition: Volume 6 Issue 3, March 2017,
Pages: 1539 - 1545
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Research Paper, Chemistry, United Kingdom, Volume 4 Issue 1, January 2015
Pages: 1527 - 1529Antibacterial Studies of Leucine Complexes of Fe (III) and Cu (II)
K. Asemave [3] | B. A. Anhwange | T. J. Anom
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Research Paper, Chemistry, India, Volume 11 Issue 7, July 2022
Pages: 125 - 132Synthesis, Characterization and In Vitro Antimicrobial Evaluation of Some New Benzofuranyl Substituted Pyrido [3, 2-C] Coumarins
Nehakumari N. Gohil | D. I. Brahmbhatt