Downloads: 102
Informative Article | Immunology | Bulgaria | Volume 5 Issue 9, September 2016
HCV Co-Infection Compromising the Effects of c-ART?An Insight from the HIV-Positive Population in Bulgaria
M. Alexandrova | E. Golkocheva-Markova,.Timchev | N. Yancheva | I. Elenkov | I.Alexiev | P. Teoharov | T. Varleva | M. Nikolova [2]
Abstract: Hepatitis C is common in HIV-positive patients and may considerably impact their prognosis. In Bulgaria, 26 % of the HIV+ patients diagnosed between 2010 and 2014 were HCV seropositive, with a very high rate of active co-infections, and multi-risk profile. Immunological and virological parameters (CD4AC, CD4/CD8, HIV viral load) at the time of HIV diagnosis were similar as compared to HIV monoinfection but deteriorated quickly until registration at hospital. Only 52 % of HIV+ patients with active HCV infection were started on c-ART. In the absence of HCV-specific therapy, they were characterised by significantly inferior immune restoration (in terms of CD4 AC and CD4/CD8 increase), and lower rate of sustained HIV virologic response (63 % vs.38 %, p<0.0001). Altogether, HCV co-infection is a significant risk factor for the progress of HIV epidemics in Bulgaria, and requires specific efforts for successful management and treatment of a multi-risk patients group.
Keywords: HIV, Hepatitis C co-infection, c-ART
Edition: Volume 5 Issue 9, September 2016,
Pages: 1732 - 1735
Similar Articles with Keyword 'HIV'
Downloads: 114
Research Paper, Immunology, Albania, Volume 6 Issue 4, April 2017
Pages: 1718 - 1723CD4+ Cell Count in the HIV/AIDS-infected People with Pulmonary Complications
Matilda Gjergji | Jul Bushati | Arjan Harxhi [12] | Dhimiter Kraja [7]
Downloads: 115 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1
Research Paper, Immunology, India, Volume 6 Issue 2, February 2017
Pages: 1063 - 1067Incidence of Gastrointestinal and Hepatobiliary Symptoms in HIV Patients
Dr. Ashtaputre Mukund D | Dr. Malviya Prashant B | Dr. Shah Malviya Apeksha P.