M. Kokori, Z. G.S. Turaki, A. T. Ahmed, A. Faisal
Abstract: This study was conducted in the malaria endemic settlements of Lake-Alau, Borno State, Nigeria, between August to December, 2012. The relationship between the mean parasite densities on days 0, 3, 7, 14 and 28 during follow-up and the trends of recoveries from thrombocytopenia in children (59 months) was conducted on Plasmodium falciparum malaria using the Standard therapeutic guidelines protocols. A sample size of 313 children was enrolled for the study, all suffered from uncomplicated Plasmodium falciparum malaria and treated with either Artesunate + Sulphadoxine - Pyrimethamine (AT+SP) and Amodiaquine + Sulphadoxine - Pyrimethamine (AQ+SP). The results shows if the study showed that there was a higher initial platelet count of 77975 x109l in AQ+SP group compared to AT+SP (55281 x 109 l) patients, and also the influence of parasitaemia on platelet distribution was relatively higher (98.30 %) in AT+SP compared to AQ+SP (95.98 %) combinations. Both drugs significantly acted in a similar pattern but the trend of mean daily reduction in parasite density per l of blood which caused a mean recovery in platelets by 48, 606 x109l in AQ+SP as against 37, 956 x109l for AT+SP over 28 days of follow-up.
Keywords: recovery, trends, thrombocytes, parasitaemia