Downloads: 122
Research Paper | Biochemistry Science | India | Volume 3 Issue 8, August 2014
Study on Significance of C- Reactive Protein Estimation in Early Diagnosis of Neonatal Septicemia
Dr Yatish Goswami | Dr Prashant Jadav | Dr Bhumika Rathod
Abstract: BACKGROUND: Septicemia is major problem in neonates. Clinical criteria alone could not establish the diagnosis of neonatal septicemia. However, empirical treatment should not be delayed because of the high mortality. C- reactive protein, an acute phase protein, increases in inflammatory disorders and tissue injury. OBJECTIVES: 1. To evaluate the diagnostic accuracy of CRP in neonatal sepsis METHOD: A prospective study included newborn infants, aged < 30 days and diagnosed with septicemia, who were admitted in neonatal intensive care unit at Sir T Hospital, Bhavnagar during 8- month period. This study included 200 cases in which 100 were culture proven septicemia and 100 normal newborn. Investigations for infection included CBC, blood culture and urine culture. RESULTS: As per present study, sensitivity of Serum CRP is 91 % and specificity being 94 % with NPV of 91.2 % suggesting its beneficial role in diagnosing sepsis. As per the study, Serum CRP was positive in 91 % of culture proven sepsis and negative in 9 % of cases. p value of the test applied for the statistical significance is < 0.05 which implies that the result is statistically significant for CRP. CONCLUSION: CRP is most commonly used laboratory test for neonatal bacterial infection and despite the continuing emergence of new infection markers it still plays a central role in the diagnosis of early onset neonatal septicemia.
Keywords: C-reactive protein CRP, Neonatal septicemia
Edition: Volume 3 Issue 8, August 2014,
Pages: 388 - 390
Similar Articles with Keyword 'protein'
Downloads: 3 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1
Research Paper, Biochemistry Science, India, Volume 11 Issue 2, February 2022
Pages: 690 - 693Extraction of PPO Enzyme from Ridge Gourd and its Potential Use in Decolorizing Dyes used in Laboratories at Undergraduate Level to Reduce Organic Pollutants
N. V. Swathi | S.Saritha
Downloads: 4 | Weekly Hits: ⮙4 | Monthly Hits: ⮙4
Research Paper, Biochemistry Science, Ivory Coast, Volume 12 Issue 7, July 2023
Pages: 71 - 81The Influence of Geographical Location of the nest on Chemical Composition of Termite Macrotermes Bellicosus Fungus Comb Collected in Cote d'Ivoire
Amessan Izihidem Amelie | Gnangui Sophie Nadege | Komade Thierry [2] | Kouame Lucien Patrice [2]