In-Vitro Antiproliferative Effect of Cancer Medicine Karumsurathi Thailam on Cultured MCF-7 Cell Line

R. Mary Suja | B. Christudhas Williams

Abstract: The main objective of the present investigation is to evaluate the phytochemical constituents, cytotoxic and antiproliferative effect of Karumsurathi Thailam prescribed by the Traditional Siddha Practitioner of Kanyakumari District, India. The external form of Breast Cancer medicine prescribed above 18 years was prepared with 18 different plant ingredients. Phytochemical analysis of the Thailam, aqueous, silver nitrate and ethanol extract revealed the presence of alkaloid, flavanoid, saponin, terpenoid and steroid constituents. Karumsurathi Thailam was tested against human breast cancer cell lines (MCF-7) and antigrowth effect was assessed by the MTT assays. L929 Fibroblast cells treated with Karumsurathi Thailam showed a decrease in viability when compared with the control. A significant decrease in cell viability of 56.10 % (1g/ml), 50.10 % (5g/ml), 42.5 % (10g/ml) and 40.92 % (20g/ml) was observed. The cytotoxic activity on cultured l929 cells and antiproliferative effect on MCF-7 cultured cells revealed the effect of Karumsurathi Thailam as a great potential source to rid and relapse from Breast Cancer.

Keywords: Siddha, Kalanchi, MTT assay, Karumsurathi Thailam, MCF-7

Edition: Volume 6 Issue 1, January 2017,

Pages: 1271 - 1274