Ousmane Niass, Amadou Diop, Khadydiatou Thiam, Rokhaya Geye, Mariko Madani, Serigne Omar Sarr, Bara Ndiaye, Yerim Mbagnick Diop
Abstract: The emergence of certain diseases such as cardiovascular diseases, diabetes, cancer, resulting from diet or environmental pollution makes relevant researches for therapeutic solutions among which, medicinal plants. It is in this perspective that we must place this study which is about the evaluation of the total polyphenol contents and the determination of the antioxidant activity of leaf and bark extracts of Combretum glutinosum. The results has shown the presence of polyphenols in all the extracts with a higher content in the extract by infusion of the leaves, which is 258, 8mg gallic acid equivalent per gram. The study of the antioxidant activity has given low IC50 values compared to those of the reference antioxidants, namely ascorbic acid and quercetin. The lowest IC50 value was obtained with fractions of the leaf infusion extract and was 0.122 g/ml with the ethyl acetate fraction and 2, 370 g/ml with the aqueous fraction for the DPPH and ABTS tests respectively.
Keywords: antioxidant, polyphenols, quercetin, Combretum