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Research Paper | Biochemistry | Nigeria | Volume 2 Issue 9, September 2013
The Impact of Zidovudine (An Antiretroviral Drug) on Some Serum and Erythrocyte Biochemical Parameters in Wistar Albino Rats
Okonkwo C.O | Uwakwe A.A.
Abstract: Zidovudine (AZT) is a nucleoside analog, a reverse transcriptase inhibitor (NRTI) and a type of antiretroviral drug used for the treatment of HIV/AIDS. The administration of zidovudine to the wistar albino rats showed an increase in erythrocyte fragility as can be seen from figure 1. There were significant (p<0.05) increases in serum Aspartate aminotranseferase (AST) activity, and Glutathione-S- transeferase (GST) activity, The result also showed non-significant (p>0.05) decrease in serum ALP activity, significant (p<0.05) decrease in Fe2+/Fe3+ ratio and NADH methaemoglobin reductase activity. Findings from this study have revealed that zidovudine is hepatotoxic, increases the concentraton of ferric iron in the body thus imparing oxygen transport and also affects the erythrocyte membrane proteins adversely.
Keywords: zidovudine, nucleoside analog, reverse transcriptase, inhibitor, antiretroviral
Edition: Volume 2 Issue 9, September 2013,
Pages: 185 - 189
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Research Paper, Biochemistry, Brazil, Volume 10 Issue 9, September 2021
Pages: 460 - 468In Vitro Antimicrobial Activity of Jamelao Seed Proteins (Syzygium Cumini (L.) Skeels)
Ana Catarina Viana Valle [5] | Andrea Maria Lazzari | Francislete Rodrigues Melo
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Research Paper, Biochemistry, Gabon, Volume 9 Issue 12, December 2020
Pages: 1021 - 1026Type 2 Diabetes and Complications at a Diabetes Tertiary Care Center of Libreville - Gabon
Aude Syntia Mbang Bengone | Rosalie Nikima-Ndong | Guy Roger Ndong Atomo | Alvine Sibylle Batou | Eudine Tsouka | Felix Ovono Abessolo | Edouard Ngou-Milama