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International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064



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Chronic Myeloid Leukemia ? An Overview

Jayita Dey Mondal, Dalia Tewary, Samadrita Mukherjee Sardar

Abstract: CML is a myeloproliferative disorder characterized by a specific cytogenetic abnormality, the Philadelphia chromosome (Ph), a balanced translocation, involving a fusion of the Abelson oncogene (ABL) from chromosome 9q34 with the breakpoint cluster region (BCR) on chromosome 22q11. The molecular consequence of this translocation is the generation of a BCR-ABL fusion oncogene, which translates into Bcr-Abl oncoprotein with increased tyrosine kinase activity. (1)

Keywords: Chronic Myeloid Leukemia



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