International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Since Year 2012 | Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064




Downloads: 107

Comparative Studies | Medicine Science | Egypt | Volume 4 Issue 9, September 2015


Additional Benefit of ?-Fetoprotein in Patients with Chronic Hepatitis B and C without Evidence of Hepatoma

Abeer M. Hafez [5] | Yasser S. Sheta [4] | Fawzy A. Elmessallamy [4] | Elsayed A. Elgohary [5] | Mansour Mursy [2]


Abstract: Alpha fetoprotein is a substance produced by a fetus' liver that can be found in the amniotic fluid and in the mother's blood. But sometimes appear in abnormally increased level in certain diseases of adults, such as liver cancer, and its level in amniotic fluid can be used to detect certain fetal abnormalities, including Down syndrome and spina bifida. The importance of ?-fetoprotein level elevation in patients with chronic viral hepatitis B and C and its clinical significance in steatosis associated with HBV and HCV infection remain to be clarified. In this study assessed the clinical significance of ?-fetoprotein in patients with chronic hepatitis B and C with and without steatosis. Methods. Alpha fetoprotein was measures in fifty patients with chronic viral hepatitis which were divided into 25 patients with chronic hepatitis B (CHB) and 25 patients with chronic hepatitis C (CHC). Both groups further subdivided based on liver biopsy into chronic hepatitis B with, without steatosis and chronic hepatitis C with, without steatosis. Results. There was statistically significant increment (p < 0.05) of the number and percentage of patients with steatosis in CHC (14, 56%) in comparison to CHB patients (9, 36%). ?-fetoprotein was significantly increased in chronic hepatitis B and C patients with steatosis (12.82 ? 5.3, 13.01 ? 7.2) than patients without steatosis (6.29?4.9, 5.94?5.9) respectively (P < 0.001). Significant positive correlation was found between serum ?-fetoprotein and the severity of fibrosis in patients with CHC with steatosis (r 0.49, p <0.05). While no significant correlation in CHB patients with steatosis. In all patients with steatosis whatever CHC or CHB, there was significant positive correlation between AFP and grade of steatosis (p <0.05, r =0.52). Conclusion. Alpha fetoprotein levels significantly increased in patients with chronic hepatitis B and C with steatosis than patients without steatosis. The percentage of patients with steatosis was significantly higher in CHC than CHB. AFP levels had significant positive correlation with the severity of steatosis in patients with chronic hepatitis C and B and severity of fibrosis in chronic hepatitis C only. So in the absence of traditional causes of elevated serum AFP, steatosis should be among the differential diagnoses of elevated serum AFP levels. In other hand elevated AFP level could be considered as a marker of steatosis in chronic hepatitis B patients and marker of steatosis and fibrosis in chronic hepatitis C patients.


Keywords: fibrosis, hepatoma, hepatitis, fetoprotein, steatosis


Edition: Volume 4 Issue 9, September 2015,


Pages: 1409 - 1414

Additional Benefit of ?-Fetoprotein in Patients with Chronic Hepatitis B and C without Evidence of Hepatoma


How to Cite this Article?

Abeer M. Hafez, Yasser S. Sheta, Fawzy A. Elmessallamy, Elsayed A. Elgohary, Mansour Mursy, "Additional Benefit of ?-Fetoprotein in Patients with Chronic Hepatitis B and C without Evidence of Hepatoma", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=SUB158320, Volume 4 Issue 9, September 2015, 1409 - 1414, #ijsrnet

How to Share this Article?

Enter Your Email Address




Similar Articles with Keyword 'fibrosis'

Downloads: 113

Research Paper, Medicine Science, Albania, Volume 4 Issue 5, May 2015

Pages: 3191 - 3193

Specific Relevance of Laboratory Examinations in Patients with Chronic Hepatic Disease-Our Experience

Nake Admir [3] | Petrela Elizana [2] | Kolpepaj Rajmonda | Hoxha Sabri [2]

Share this Article

Downloads: 115

Case Studies, Medicine Science, Albania, Volume 5 Issue 5, May 2016

Pages: 1276 - 1278

Multifocal Choroiditis Complications (CNV) Treatment: A Case Report

Nadon QAFA.

Share this Article


Top