International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064




Downloads: 129 | Monthly Hits: ⮙1

Research Paper | Biology | United States of America | Volume 4 Issue 9, September 2015


Cancer Associated MicroRNAs are Differentially Expressed in Triple Negative Breast Cancer and Normal Breast Cells

Sherette S. Godfrey, Malcolm M. Moses, Checo J. Rorie


Abstract: Breast cancer is a heterogeneous disease that is sub-categorized based on the expression of certain protein markers including estrogen and progesterone. Triple-negative breast cancer (TNBC) is a subtype of breast cancer that is characterized by its lack of the estrogen, progesterone and HER2/Neu protein receptors, and it has no known biomarkers for diagnosis and drug targeting. TNBC has a high mitotic index and primarily affects women of African origin. MicroRNAs are small non-coding RNA molecules that regulate oncogenic and tumor suppressive pathways in the cel1, and may potentially be used as biomarkers for the diagnosis and prognosis of TNBC. In this study, we compared the expression of microRNAs that play roles in cancer in TNBC cell lines (HCC1806, HCC70, and MDA-MB-157) and normal breast cells (AG11132). Microarray analysis revealed that microRNAs 21, 34a, 103, 141, and let-7a were shown to be differentially expressed in TNBC cells vs. the normal breast tissue cell lines. Quantitative-PCR confirmed the differential expression of the microRNAs in the TNBC cell lines vs the normal cells. These findings suggest that microRNAs could be used as potential biomarkers to diagnose TNBC and could potentially be used as drug-targeted therapies in the future.


Keywords: breast cancer, TNBC, microRNA, miRNA, qPCR


Edition: Volume 4 Issue 9, September 2015,


Pages: 73 - 78


How to Cite this Article?

Sherette S. Godfrey, Malcolm M. Moses, Checo J. Rorie, "Cancer Associated MicroRNAs are Differentially Expressed in Triple Negative Breast Cancer and Normal Breast Cells", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=SUB157954, Volume 4 Issue 9, September 2015, 73 - 78

How to Share this Article?

Enter Your Email Address


Similar Articles with Keyword 'breast cancer'

Downloads: 105

Research Paper, Biology, India, Volume 5 Issue 11, November 2016

Pages: 726 - 732

Biosynthesis of Omega 3fatty Acids and the Activation of Anticancerous Effect in Human

Dr. Y. Thangam, B. Ranchitha

Share this Article

Downloads: 108

Research Paper, Biology, United States of America, Volume 4 Issue 9, September 2015

Pages: 1024 - 1028

Triple Negative Breast Cancer Cell Lines with TP53 Mutations are Able to Undergo Cell Death

Veronica L. Stallings, Kashenya M. Gurley, Checo J. Rorie

Share this Article

Similar Articles with Keyword 'breast'

Downloads: 105

Research Paper, Biology, India, Volume 5 Issue 11, November 2016

Pages: 726 - 732

Biosynthesis of Omega 3fatty Acids and the Activation of Anticancerous Effect in Human

Dr. Y. Thangam, B. Ranchitha

Share this Article

Downloads: 107

Research Paper, Biology, India, Volume 3 Issue 11, November 2014

Pages: 1703 - 1707

Design of Aptamer-Gold Nanoparticles Based Colorimetric Assay for the Early Diagnosis of Breast Tumor

Nandita P. Agnihotri, Mangla Bhide

Share this Article

Similar Articles with Keyword 'cancer'

Downloads: 105

Research Paper, Biology, India, Volume 5 Issue 11, November 2016

Pages: 726 - 732

Biosynthesis of Omega 3fatty Acids and the Activation of Anticancerous Effect in Human

Dr. Y. Thangam, B. Ranchitha

Share this Article

Downloads: 107

Research Paper, Biology, India, Volume 4 Issue 12, December 2015

Pages: 1362 - 1366

New Aryl Derivatives of Acridine with Poly (ADP- Ribose) Polymerase 1 Inhibitory Activity: A Molecular Modeling Approach

Sayantani Karmakar, Rita Ghosh

Share this Article
Top