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Research Paper | Medicine Science | Indonesia | Volume 4 Issue 8, August 2015
The Role of Inflammation in the Benign Prostatic Hyperplasia Pathogenesis
Amir Azwar, Yusuf Irawan, Patellongi Ilhamjaya, Sinrang Wardihan, Rasyid Nur
Background This study aimed to analyze the role of proinflammatory cytokines TNF and anti-inflammatory IL-10 in the pathogenesis of benign prostatic hyperplasia. Methods This research is an correlative analytical study with validity test, comparing the levels of pro-inflammatory cytokines TNF- and anti-inflammatory mediators IL-10 with prostate volume in benign prostatic hyperplasia patients. Result Based on correlation test in BPH patients with prostatitis, prostate volume strongly relates with TNF and IL-10. This showed in the significant value of less than 0.05. So, TNF- and IL-10 has a strong relationship with the size of the prostate volume in BPH patients. There is tendency when the TNF- and IL-10 increased, prostate volume is also increased. Based on the normality data test for prostate volume, obtain result sig = 0.113> 0.05, that mean the data is concomitant with the normal distribution. Then analyzed by linear regression, the results showed that each increase of TNF 1 pg / ml, the prostate volume will also tend to increase by 3.345 ml. The value of R2 at 29.4 % provides that the effect of TNF to the prostate volume is 29.4 %, the remaining (70.6 %) is came from other factors. When the IL 10 increased 1 level, the prostate volume tends to increased by 1.196, the determination coefficient (R2) is 15 % which means that only 15 % of the effect of IL-10 on prostate volume, the remaining 85 % comes from other factors. Conclusion Levels of TNF- and IL-10 have a very strong correlation with the prostate volume in benign prostatic hyperplasia patient. If there is an increased of TNF-, the prostate volume will also increased. Same as IL-10. Inflammatory mediators play a role in the increasing of prostate volume and prostate proliferation cell inflammatory grading. So it can be concluded that chronic inflammation plays a role in the pathogenesis of benign prostatic hyperplasia.
Keywords: benign prostatic hyperplasia, tumor necrosis factor, interleukin-10
Edition: Volume 4 Issue 8, August 2015
Pages: 1675 - 1678
How to Cite this Article?
Amir Azwar, Yusuf Irawan, Patellongi Ilhamjaya, Sinrang Wardihan, Rasyid Nur, "The Role of Inflammation in the Benign Prostatic Hyperplasia Pathogenesis", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=SUB157589, Volume 4 Issue 8, August 2015, 1675 - 1678
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