International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Since Year 2012 | Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064




Downloads: 114

Research Paper | Cardiology Science | Bulgaria | Volume 4 Issue 7, July 2015


KIM-1 to Urinary Creatinine Ratio for Early Detection of AKI in Patients Undergoing Cardiopulmonary Bypass

Julieta Hristova [2] | Antoaneta Dimitrova | Georgi Tsaryanski | Kamen Tzatchev | Gencho Nachev


Abstract: Acute kidney injury (AKI) is a common serious complication among patients undergoing on-pimp cardiac surgery. Currently its diagnosis is based on the accumulation of nitrogen metabolism end products such as sCreat (serum creatinine) which is known to be late and unreliable marker for AKI for its levels are affected by different extrarenal variables. In recent years, several urinary markers of tubular damage have been proposed as more accurate alternatives to serum creatinine for the early detection of AKI in patients undergoing CPB (cardiopulmonary bypass). The objective of our study was to assess the performance characteristics of urinary KIM-1 measured 2-6 hours post surgery among adults undergoing CPB and to compare the predictive value of urinary KIM-1 with urinary KIM-1 to urinary creatinine ratio. ROC (receiver operator characteristics) -analysis revealed 2-6 hours post-CPB urinary KIM-1 AUC (area under the curve) of 0.84 (p<0.001). For calculated urinary KIM-1 to urinary creatinine ratio the ROC analysis revealed an enhanced performance with AUC 0.85 (p<0.001) giving AUC of 0.01. Using normalized values demonstrated a higher predictive value for urinary KIM-1 to urinary creatinine ratio for early detection of AKI compensating some of the shortcomings of absolute values determination related with effective extrarenal modifiers of the results.


Keywords: Acute kidney injury, early diagnosis, cardiopulmonary bypass, kidney injury molecule-1


Edition: Volume 4 Issue 7, July 2015,


Pages: 2196 - 2198

KIM-1 to Urinary Creatinine Ratio for Early Detection of AKI in Patients Undergoing Cardiopulmonary Bypass


How to Cite this Article?

Julieta Hristova, Antoaneta Dimitrova, Georgi Tsaryanski, Kamen Tzatchev, Gencho Nachev, "KIM-1 to Urinary Creatinine Ratio for Early Detection of AKI in Patients Undergoing Cardiopulmonary Bypass", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=SUB157006, Volume 4 Issue 7, July 2015, 2196 - 2198, #ijsrnet

How to Share this Article?

Enter Your Email Address




Similar Articles with Keyword 'early diagnosis'

Downloads: 0

Case Studies, Cardiology Science, Morocco, Volume 10 Issue 5, May 2021

Pages: 513 - 516

Unwelcomed Guest to the Heart: Secondary Cardiac Localization of Non-Hodgkin's Lymphoma: About a Case and Review of Literature

Soumia Faid | Amina Samih | Nadif Meryem | Nadia Loudiyi | Zaimi Achraf | Najat Mouine | Ilyass Asfalou | Aatif Benyass [3]

Share this Article

Downloads: 2

Case Studies, Cardiology Science, Indonesia, Volume 10 Issue 5, May 2021

Pages: 1049 - 1051

Women with Persistent Left Ventricular Systolic Dysfunctionin Peripartum Cardiomyopathy - A Case Report

I Putu Adi Palguna | I Gusti Ayu Suryawati

Share this Article


Top