International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Open Access | Double Blind Reviewed

ISSN: 2319-7064


Downloads: 114

Research Paper | Medicine Science | Bulgaria | Volume 4 Issue 1, January 2015


Endometriosis and Serum Hepcidin Levels

Manolov V [3] | Marinov B [3] | Vasilev V [3] | Tzatchev K [3] | Hadjiev E | Bogov I [2] | Hadjidekova S [2] | Genchev G [2] | Emilova R [2]


Abstract: Aim Endometriosis is a benign disease which takes third place in gynecological morbidity after inflammatory disease and uterine myoma. We tried to evaluate serum iron and hepcidin levels and search for a connection in occurrence of endometriosis. Data For serum hepcidin quantification we used ELISA assay.40 women, average age 25.4 4.3 were included. They were divided into two groups women with endometriosis (EM) and control group. The samples were taken in the University Hospital Michin Dom for a period of one year, 2014. We measure serum iron levels, ferritin and calculate transferrin saturation. Pearsons coefficient and Students t-test were used for evaluation of correlation and statistical significance. Results We found statistically significant differences in serum hepcidin levels between measured groups women with endometriosis had higher concentrations 57.4 8.5 g/L vs control group 20.7 2.8 g/L (r = -0.174, P < 0.001). Serum ferritin levels showed significant differences between two groups EM 18.3 9.6 ng/mL vs control 68.99 16.1 ng/mL (r = -0.203, P < 0.001). Serum iron levels were statistically different for EM 48.9 4.9 mol/L compared to 11.6 1.7 mol/L in control group (P < 0.001). Conclusions We conclude that our results support the thesis that iron overload and elevated serum hepcidin levels takes an important role into pathogenesis of endometriosis.


Keywords: endometriosis, hepcidin, iron overload, ferritin, inflammation


Edition: Volume 4 Issue 1, January 2015,


Pages: 2428 - 2430


How to Download this Article?

You Need to Register Your Email Address Before You Can Download the Article PDF


How to Cite this Article?

Manolov V, Marinov B, Vasilev V, Tzatchev K, Hadjiev E, Bogov I, Hadjidekova S, Genchev G, Emilova R, "Endometriosis and Serum Hepcidin Levels", International Journal of Science and Research (IJSR), Volume 4 Issue 1, January 2015, pp. 2428-2430, https://www.ijsr.net/get_abstract.php?paper_id=SUB15694

Similar Articles with Keyword 'iron overload'

Downloads: 119

Research Paper, Medicine Science, India, Volume 5 Issue 7, July 2016

Pages: 1402 - 1405

Correlation between Plasma Protein Carbonyl Adducts and RBC Reduced Glutathione Level in Beta Thalassemia Major Patients in Southern Asian Region

Tanima Mandal | Santa Saha | Pradipta Ghosh | Suman Chatterjee | Pinaki Sarkar

Share this Article

Downloads: 158

Research Paper, Medicine Science, Iraq, Volume 5 Issue 2, February 2016

Pages: 78 - 82

The Role of Reproductive Hormones on Fertility with Beta-Thalassemia

Muhammad O. Al-Muhammadi | Bushra J. Al-Rubaie | Mais A. Al-Turaihi

Share this Article
Top