International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Since Year 2012 | Open Access | Double Blind Reviewed

ISSN: 2319-7064




Downloads: 106

Research Paper | Medicine Science | Pakistan | Volume 4 Issue 5, May 2015


The Efficacy of Pharmacological Intervention in a Subset of Hyperglycemic Pakistani Population

Adeel Ahmed Shamim | Nayla Ahmed | Asifa Alia [2] | Najmul Islam | Bushra Chaudhry [2]


Abstract: Treatment of type II diabetes with oral anti-hyperglycemic drugs is initially successful, but the inclusion of insulin in the treatment regime is eventually inevitable under poor control. This paper aims to provide an overview of anti-hyperglycemic drugs and their use in Pakistan population coupled with their efficacy in treatment of diabetes type II. Literature search identified 140 clinical trials and 26 observational studies that compared mono or combination therapies. Further a retrospective review of 1518 patients which were undergoing treatment for type II diabetes mellitus in outpatient department (OPD) of endocrinology unit of Aga Khan University Hospital during 2007-2010 was done. The inclusion criteria for study subjects favored of age between 35-65 years with duration of diabetes between 5-35 years. The data was collected from hospital record department and was analyzed for efficacy of the medications using SPSS. V16. Prescribed oral anti-hyperglycemic drugs were independent of diabetes duration. Insulin, Biguanides, Sulfonylureas, Thiazolidinediones and Alpha-glycosidase were preferred to use singly or in combination. Overall insulin usage with other combination was in 56 % of patients while overall Biguanides and sulfonylureas usage was in 61 % and 45 % of patients respectively. In response to therapy, the achieved FBS level, below 110 mg/dl, was in 21 % of patients, levels as >110 to 126 mg/dl (CI 95 %, OR 2.74, p=0.0006). Insulin and Biguanides were found efficacious in only 34 % of selected population to bring the glycemic levels at normal limits when employed singly or in combination. Poorly controlled glycemic levels in 66 % of population indicate co-morbidities and future complications of diabetes. All the current anti-hyperglycemic medications existing in global market were not being used in Pakistani population. Further genetic variation affecting drug metabolism may be the cause of decreased efficacy of drugs. The results can aid diabetologists, physicians and patients in making informed choices for better management of type II diabetes.


Keywords: Diabetes type II, Anti-hyperglycemic drugs, Efficacy of Anti-hyperglycemic agents


Edition: Volume 4 Issue 5, May 2015,


Pages: 2392 - 2399


How to Cite this Article?

Adeel Ahmed Shamim, Nayla Ahmed, Asifa Alia, Najmul Islam, Bushra Chaudhry, "The Efficacy of Pharmacological Intervention in a Subset of Hyperglycemic Pakistani Population", International Journal of Science and Research (IJSR), Volume 4 Issue 5, May 2015, pp. 2392-2399, https://www.ijsr.net/get_abstract.php?paper_id=SUB154655

How to Share this Article?






Similar Articles with Keyword 'Diabetes'

Downloads: 1

Research Paper, Medicine Science, Albania, Volume 4 Issue 3, March 2015

Pages: 2210 - 2212

Risk Factors in Heart Attack

Edi Smajlaj [2] | Sabit Brokaj [2]

Share this Article

Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Case Studies, Medicine Science, Indonesia, Volume 11 Issue 2, February 2022

Pages: 71 - 74

Coronavirus Disease 2019 (COVID-19) Precipitating Diabetic Ketoacidosis in Controlled Diabetes Mellitus Patient: A Case Report

Nyoman Angga Santosa [2] | Dewi Catur Wulandari [9]

Share this Article


Top