An Integrative Approach for In Silico Study on Treating Molluscum Contagiosum with Snail Slime
International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
www.ijsr.net | Open Access | Fully Refereed | Peer Reviewed International Journal

ISSN: 2319-7064

Downloads: 113

Research Paper | Biology | India | Volume 4 Issue 4, April 2015

An Integrative Approach for In Silico Study on Treating Molluscum Contagiosum with Snail Slime

Deepak Tom Jose, Caroline Nirmala. R

The dermatological disease Molluscum contagiosum (MC) presents as lesions restricted solely to the skin. The poxvirus Molluscum contagiosum virus (MCV) is responsible for this skin disease. There are four subtypes of MCV MCV-1, MCV-2, MCV-3, and MCV-4. MCV-1 is the most commonly reported subtype found. The MCV MC159 protein belong to a family of proteins known as FLICE, FADD-like interleukin-1 -converting enzyme-inhibitory proteins (FLIPs). MC159 is characterized by the presence of two tandem death effector domains (DEDs) that regulate/inhibit Apoptosis. Apoptosis is an effective mechanism to destroy virus-infected cells. Snail Extract contains an extraordinary combination of natural ingredients that have proven beneficial healing properties for the human skin. Snail extract is rich in natural antibiotics and hydroxyl-acids which are excellent ingredients for regeneration of new skin. Snail extract contains Allantoin, Glycolic Acid, Collagen, Vitamin E, Vitamin C, Vitamin A and Elastin-all wonderful and, very important ingredients for healthy skin. Allantoin helps reduce scars and stretch marks. This study includes inhibitory effects of Allantoin (C4H6N4O3), a secondary metabolite present in the Snail slime of Snail Helix Aspersa which is approved in dermatology by FDA, against MC159 protein which inhibits the Apoptosis. And further docking study was performed using Accelerys Discovery studio 4.0. Further the drug was again scanned using another chemo informatics tools to check whether it has fulfilled the condition as a drug candidate.

Keywords: Apoptosis, MC159, MCV, Allantoin, DED

Edition: Volume 4 Issue 4, April 2015

Pages: 1950 - 1954

Share this Article

How to Cite this Article?

Deepak Tom Jose, Caroline Nirmala. R, "An Integrative Approach for In Silico Study on Treating Molluscum Contagiosum with Snail Slime", International Journal of Science and Research (IJSR), https://www.ijsr.net/search_index_results_paperid.php?id=SUB153226, Volume 4 Issue 4, April 2015, 1950 - 1954

Enter Your Email Address




Similar Articles with Keyword 'Apoptosis'

Downloads: 67 | Monthly Hits: ⮙1

Research Paper, Biology, India, Volume 9 Issue 12, December 2020

Pages: 438 - 448

Identification and Analysis of GeneExpression in Flies Brain: An Insilico Approach

Arpita Parakh, Naveen Dhingra

Share this Article

Downloads: 107

Research Paper, Biology, United States of America, Volume 4 Issue 9, September 2015

Pages: 1024 - 1028

Triple Negative Breast Cancer Cell Lines with TP53 Mutations are Able to Undergo Cell Death

Veronica L. Stallings, Kashenya M. Gurley, Checo J. Rorie

Share this Article

Downloads: 113

Research Paper, Biology, India, Volume 4 Issue 4, April 2015

Pages: 1950 - 1954

An Integrative Approach for In Silico Study on Treating Molluscum Contagiosum with Snail Slime

Deepak Tom Jose, Caroline Nirmala. R

Share this Article

Downloads: 114

Research Paper, Biology, India, Volume 3 Issue 6, June 2014

Pages: 1111 - 1120

Comparative Evaluation of Immune Protective Effect of Melatonin and Boerhaavia diffusa in Lymphoid Tissues of Park's Strain Mice against Antibiotic Induced Oxidative Stress

Somenath Ghosh, Shweta Sharma, Abhinav Joshi, Chandana Haldar

Share this Article

Downloads: 143

Research Paper, Biology, India, Volume 2 Issue 9, September 2013

Pages: 12 - 18

Caspase Dependent Apoptosis is Only Inhibited on y Irradiation of Cells Conditioned by Repetitive Oxidative Stress

Rita Ghosh, Koyeli Girigoswami, Dipanjan Guha

Share this Article

Similar Articles with Keyword 'MCV'

Downloads: 113 | Weekly Hits: ⮙5 | Monthly Hits: ⮙10

Research Paper, Biology, India, Volume 3 Issue 8, August 2014

Pages: 1911 - 1914

Haematological and Serum Biochemical Parameters in different Sexes of Walking Cat Fish, Clarias batrachus (Linnaeus, 1758)

Gayatri Acharya, Prafulla K. Mohanty

Share this Article

Downloads: 113

Research Paper, Biology, India, Volume 4 Issue 4, April 2015

Pages: 1950 - 1954

An Integrative Approach for In Silico Study on Treating Molluscum Contagiosum with Snail Slime

Deepak Tom Jose, Caroline Nirmala. R

Share this Article

Downloads: 115

Research Paper, Biology, Iraq, Volume 4 Issue 3, March 2015

Pages: 2326 - 2331

Hematological and Clinical Changes in Rabbits Exposed to Lantana Camara under Experimental Conditions

Al-Khafaji Mayada Nazar

Share this Article

Downloads: 118

Research Paper, Biology, Libya, Volume 4 Issue 2, February 2015

Pages: 2053 - 2063

Protective Effects of Sesame Oil against Lead Acetate Induced Haemato-Biochemical Toxicity in Albino Mice

Azab El-Sayed Azab, El-Dakhly.A.T, Qutaiba K. Alrawi, Mohamed O. Albasha

Share this Article

Similar Articles with Keyword 'DED'

Downloads: 66

Research Paper, Biology, India, Volume 9 Issue 10, October 2020

Pages: 1538 - 1538

Host Association of the Pest Intercta in Relation to Season

Dr Sanjay Sharad

Share this Article

Downloads: 78

Research Paper, Biology, Afghanistan, Volume 9 Issue 10, October 2020

Pages: 997 - 1001

Phylogeny of Passeriformes (Aves) of Afghanistan with the Emphasis of Herat Province

Shahnaz Teimuri

Share this Article

Downloads: 80 | Weekly Hits: ⮙7 | Monthly Hits: ⮙14

Research Paper, Biology, Uzbekistan, Volume 9 Issue 11, November 2020

Pages: 1342 - 1344

Parasitofauna of Certain Species of Fish Lowves Rivers Amudarya

Kurbanova A. I.., Utemuratova F.Zh

Share this Article

Downloads: 87

Survey Paper, Biology, Indonesia, Volume 6 Issue 1, January 2017

Pages: 1358 - 1362

Integrating the Social Interaction System of Dalihan Na Tolu into the Problem Based Learning on Biology Subjects to Increase Students Achievement

Widya Arwita, Mohamad Amin, Herawati Susilo, Siti Zubaidah

Share this Article

Downloads: 89

Research Paper, Biology, Ivory Coast, Volume 9 Issue 4, April 2020

Pages: 160 - 167

Human Health Risk Assessment and Effectssome Heavy Metals in the Tissue of Two Species of Cichlidae (Hemichromisfasciatus and Tilapia zillii x Tilapia guineensis) from the Western Part of the Ebrie Lagoon, Cote Divoire

KOUAMENAN N'zebo Moise, COULIBALY Safiatou, ATSE Boua Celestin, GOORE Bi Gouli

Share this Article



Top