Research Paper | Pharmacology Science | India | Volume 4 Issue 3, March 2015
Evaluation of Antiangiogenic and Antiproliferative Efficacy of 3 Phytochemicals with Special Reference to Anthocyanins
Trisha Saxena, Arif Bashir
Abstract: Angiogenesis and cell proliferation are the major pathological components of cancer. Angiogenesis means the growth of neovessels from the existing vessels. It is tightly regulated by various inhibitors and stimulators in vivo and takes place at the time of embryogenesis and wound healing. It is primarily recruited by the solid tumors for receiving more nutrients and oxygen for the continuously dividing cells. Proliferation is the pathway from neoplasm to hyperplasm and ultimately leads to metastasis. These days they are attractive targets to cure tumors and malignancy. Wide ranges of plants contain many bioactive compounds documented for antiangiogenic and antiproliferative property. Anthocyanin is one of the bioactive ingredients documented for possessing antiangiogenic and antiproliferating potential. Anthocyanin containing Solanum melongena, Brassica olerecea and Amaranthus cruentus investigated for their antiangiogenic and antiproliferative potential utilizing Chorioallantoic membrane assay and MTT antiproliferation assay respectively. The results have shown that all crude extracts have shown antiangiogenic potential and antiproliferating activity and their potential increases with increasing dose. The antiproliferating activity was found in all three extracts but its maximum in Amaranthus cruentus and antiangiogenic property was highest in Solanum melongena.
Keywords: Anthocyanin, plant extracts, cancer, angiogenesis, antiproliferative, analysis
Edition: Volume 4 Issue 3, March 2015,
Pages: 217 - 221
How to Cite this Article?
Trisha Saxena, Arif Bashir, "Evaluation of Antiangiogenic and Antiproliferative Efficacy of 3 Phytochemicals with Special Reference to Anthocyanins", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=SUB151616, Volume 4 Issue 3, March 2015, 217 - 221
How to Share this Article?
Similar Articles with Keyword 'plant extracts'
In vitro Antioxidant Activity and Phytochemical Screening of Achyranthes aspera
Antioxidant Properties of Selected Wild Plants
Nessrin Ghazi Alabdallat, Y. Bilto
Similar Articles with Keyword 'cancer'
Anticancer Property of Simple Ascidian Phallusia Nigra Savigny, 1816 against MDA-MB-231 Cells
M. Paripooranaselvi, V. K. Meenakshi
Chemotherapeutic Properties of Naturally Occurring Stilbene Polyphenol-Resveratrol
K M Srinivasa Murthy, M Narayanappa, H Krishna Ram
Similar Articles with Keyword 'analysis'
Meropenem and Valproic Acid Interaction: A Systematic Review of Case Reports and Case Series
Mar?a Graciela Lopez Ordieres, Camila Monte Final, Micaela Ventura, Mar?a S. Viola
Evaluation of Analgesic Activity of Paroxetine in Adult Male Albino Rats in Comparison with Diclofenac
C. Umamaheshwari, M. Shanthi M. D, M. Malathi M.D, R. Parameswari M.D