International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Open Access | Fully Refereed | Peer Reviewed

ISSN: 2319-7064


Downloads: 103 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Research Paper | Genetics Science | India | Volume 3 Issue 12, December 2014


Association of GSTM1 & HMOX-1 Gene Polymorphisms in COPD: A study from South Indian Population

Ashrafunnisa Begum, A. Venkateshwari, N Balakrishna, A. Jyothy


Abstract: The major risk factor for COPD is smoking. The pathology involves the imbalance of oxidant/antioxidant mechanism. As smoking enhances, the Oxidative stress increases thereby decreasing the antioxidants capacity in airways causing damage to normal lung function. The aim of the present study was to evaluate the role of (Glutathione GSTM1 & T1) and HMOX-1 gene polymorphism in COPD and control subjects from Telangana state of India. GSTM1 and T1 gene polymorphism was evaluated by Multiplex polymerase chain reaction and HMOX-1 by ARMS-PCR in 250 COPD with equal number of control subjects. Appropriate statistics using students t test, Fischer exact test, chi-square with Hardy Weinberg equllibrium were applied for the analysis. There was a significant association of GSTM1 null genotype with the disease (2= 18.82; p=0.0001; OR=2.21; CI=1.543-3.18). Significant association was also found between the GC genotypes of HMOX-1 gene in COPD patients (2= 3.73; p=0.05; OR=1.52; (CI=0.9927-2.352) compared with controls. However further studies from other populations are needed to confirm this results.


Keywords: Chronic Obstructive Pulmonary Disease COPD, Glutathione Transferase - 1 GSTM1, Glutathione tranferase T1 GSTT1 and Heameoxygenase -1 HMOX-1


Edition: Volume 3 Issue 12, December 2014,


Pages: 318 - 324


How to Cite this Article?

Ashrafunnisa Begum, A. Venkateshwari, N Balakrishna, A. Jyothy, "Association of GSTM1 & HMOX-1 Gene Polymorphisms in COPD: A study from South Indian Population", International Journal of Science and Research (IJSR), https://www.ijsr.net/get_abstract.php?paper_id=SUB14347, Volume 3 Issue 12, December 2014, 318 - 324

How to Share this Article?

Enter Your Email Address


Similar Articles with Keyword 'Chronic'

Downloads: 98 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Review Papers, Genetics Science, India, Volume 4 Issue 12, December 2015

Pages: 2157 - 2164

Signaling of IL 4 and IL 13 Genetic Variants in Asthma Pathogenesis

Pratibha Dixit, Shally Awasthi

Share this Article

Downloads: 105

M.Tech / M.E / PhD Thesis, Genetics Science, Iraq, Volume 6 Issue 4, April 2017

Pages: 2107 - 2113

Cell Free miRNAs (146a and 26a) Expression in Plasma and Saliva as Potential Biomarkers in Newly Diagnosed Rheumatoid Arthritis Patients

Mayyadah H. Rashid, Raja H. Al-Jubouri

Share this Article

Similar Articles with Keyword 'Disease'

Downloads: 86 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Review Papers, Genetics Science, India, Volume 9 Issue 6, June 2020

Pages: 818 - 821

Role of Cytogenetics and Molecular Genetics in Cancer Research

Dr. Alibha Rawat, N. Ganesh

Share this Article

Downloads: 99

Research Paper, Genetics Science, India, Volume 4 Issue 4, April 2015

Pages: 3370 - 3371

Effect of Sumac on Human DNA

Sumera Naaz, Umamah Iram, Nousheen Fatima, Dr. Venugopal Rao, Dr. Elizabeth Margaret

Share this Article
Top