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Student Project | Pharmacology Science | India | Volume 12 Issue 1, January 2023

Formulation and Evaluation of Immediate Release Tablet of Metformin Hydrochloride

Deepali Balwant Ranmale | Dr. Rupali R. Tasgaonkar | Puja G. Vyawhare

Abstract: The purpose of this research is to prepare metformin hydrochloride immediate release tablets by wet granulation technique. In order to obtain the best, optimized product ten different formulations were developed. Different binder, disintegrants and lubricants taken as variables. Weight variation, thickness, hardness, friability, disintegration time, in-vitro release and pharmaceutical assay were studied as response variables. The tablet were prepared by direct compression method & later evaluated for parameters. F1-F6 formulation were developed using different combination of Cross carmesllose sodium & Sodium starch glycolate (super disintegrants). Formulations F1 & F2 was compared within formulations shown a release of 90-99%. Formulation F1 (Metformin = 250mg, Cross carmellose sodium = 30mg, Sodium starch glycolate = 14mg, Microcrstalline cellulose = 70mg, Cross Povidone = 16, Magnesium sterate = 20mg) & Formulation F2 (Metformin = 250mg, Cross carmellose sodium = 30mg, Sodium starch glycolate = 10mg, Microcrstalline cellulose = 70mg, Cross Povidone = 20, Magnesium sterate = 20mg) has shown better drug release than other formulations. F1 & F2 has 95.8% & 99.9% drug release respectively.

Keywords: Metformin hydrochloride, optimization, anti-diabetic drug

Edition: Volume 12 Issue 1, January 2023,

Pages: 401 - 403

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