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Research Paper | Pathology | India | Volume 12 Issue 1, January 2023

Gliosarcoma: A Rare Variant of Glioblastoma Multiforme: Case Report

Dr. Nirali U Patel | Dr. Viral M Bhanvadia | Dr. Hansa Goswami ^[14]

Abstract: Introduction: Gliosarcoma is rare central nervous system tumour and a variant of glioblastoma multiforme with bimorphic histological pattern of glial and sarcomatous differentiation. It occurs in elderly between 5th and 6th decades of life and extremely rare in children. It is highly aggressive tumour and managed like glioblastoma multiforme. Case report: A 48 years old female patient presented to neurosurgery department with chief complaints of altered sensoriumX 1 days. Magnetic resonance imaging of brain shows s/o Aggressive Oligodendroglioma /Glioblastoma Multiforme, Frozen section shows histology of highgrade glioma-Glioblastoma with small cell component and pleomorphic spindle cell component WHO Grade-IV with complete excision of mass revealed a primary glioblastoma with sarcomatoid differentiation on histopathological investigation which is confirm by Immuno-Histochemistry. Methods: Multiple sections are taken from given biopsy and stain by H&E stain and For Immuno-histochemistry stain done by P53, G-FAP, Vimentin and EMA. Result: Final diagnosis is High Grade CNS tumor-suggestive of Glioblastoma with predominant sarcomatoid differentiation-WHO Grade IV confirmed by Histological and Immuno-histochemistry.

Keywords: Gliosarcoma, Glioblastoma multiforme, Microvascular proliferation, Mixed tumor, Radiotherapy

Edition: Volume 12 Issue 1, January 2023,

Pages: 495 - 498

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