International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Open Access | Double Blind Reviewed

ISSN: 2319-7064


Downloads: 1 | Weekly Hits: ⮙1 | Monthly Hits: ⮙1

Comparative Studies | Anaesthesiology | India | Volume 11 Issue 8, August 2022


A Comparative Study of Nalbuphine and Fentanyl as Adjuvant to Thoracic Epidural Ropivacine for Post Operative Analgesia in Laparotomy Surgeries

Dr. (Mrs.) Anita Pareek | Dr. Kiwi Mantan | Dr. Pramila Soni | Dr. Manish Kumar Verma | Dr. Jinesh Baid | Dr. Priyanka Kumari


Abstract: Background: A prospective, double-blind, randomized study was carried out to compare the quality of postoperative analgesia and side-effect profile between epidurally administered fentanyl and nalbuphine as an adjuvant to 0.2% ropivacaine. Postoperative pain therapy for abdominal surgeries is important far beyond the perioperative period because sensitization to painful stimuli can cause postoperative morbidity. Materials and Methods: A total of 60 patients between the age of 18 and 65 years of American Society of Anesthesiologists (ASA) Class I E and II E who underwent laparotomy surgeries were randomly allocated into three groups. Group 1 received 13 ml of 0.2% ropivacaine with 10 mg (1ml) nalbuphine (Total volume 14 ml), Group 2 received 13 ml of 0.2% ropivacaine with 50?g (1ml) fentanyl in epidural catheter (Total volume 14 ml) and Group 3 received 14 ml of 0.2% ropivacaine in thoracic epidural catheter. Quality of analgesia, cardiorespiratory parameters, side-effects, and the need of rescue intravenous analgesia were observed. Results: Mean VAS score was lower in G 1 (0.75?0.91) and it was statistically significant when compared to G 2 (1.35?0.99) and G 3 (1.55?1.05), (p value = 0.035). Thus the requirement of 24 hours rescue analgesic in term of number was lower in G 1(0.50?0.61) when compared to group 2 (0.85?0.67) and group 3 (2.20?0.70), which was statistically significant. (p value = 0.0001). Systolic BP, diastolic BP and mean arterial BP were maintained and comparable in all three groups during first 24 hours of postoperative period (p value > 0.05). Pulse rate was rate was lower and it was statistically significantly in first 15 minutes in group 3 as compared to group 1, group 2. (p value < 0.05) However after that pulse rate was comparable in all three groups during first 24 hours of postoperative period (p value > 0.05). Side effects were comparable in group 1, group 2 and group 3 and were statistically insignificant. (p value > 0.05). Conclusion: Thoracic epidurally administrated ropivacaine with nalbuphine is more effective than ropivacaine with fentanyl for postoperative analgesia up to 24 hours of the postoperative period in laparotomies.


Keywords: fentanyl, emergency laparotomy, nalbuphine, postoperative analgesia, ropivacaine, thoracic epidural


Edition: Volume 11 Issue 8, August 2022,


Pages: 598 - 602


How to Download this Article?

You Need to Register Your Email Address Before You Can Download the Article PDF


How to Cite this Article?

Dr. (Mrs.) Anita Pareek, Dr. Kiwi Mantan, Dr. Pramila Soni, Dr. Manish Kumar Verma, Dr. Jinesh Baid, Dr. Priyanka Kumari, "A Comparative Study of Nalbuphine and Fentanyl as Adjuvant to Thoracic Epidural Ropivacine for Post Operative Analgesia in Laparotomy Surgeries", International Journal of Science and Research (IJSR), Volume 11 Issue 8, August 2022, pp. 598-602, https://www.ijsr.net/get_abstract.php?paper_id=SR22803220212

Similar Articles with Keyword 'fentanyl'

Downloads: 0

Research Paper, Anaesthesiology, India, Volume 11 Issue 5, May 2022

Pages: 1191 - 1195

Comparative Study of Intravenous Fentanyl Vs Nebulisation Fentanyl for Postoperative Analgesia in Patients Undergoing Lower Limb Surgeries - A Randomised Controlled Study

Dr. Thillai Arasu | Dr. Pradeep Charan | Dr. Arun Satish | Dr. S. P. Chittora [3]

Share this Article

Downloads: 1

Masters Thesis, Anaesthesiology, India, Volume 10 Issue 6, June 2021

Pages: 568 - 569

A Study Comparing the Efficacy of Postoperative Analgesia with Fascia-Iliaca Compartmental Block vs IV Tramadol In Surgeries Around Hip

Dr. Firdous Fatima | Dr M. H. Nagrale

Share this Article
Top