International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Since Year 2012 | Open Access | Double Blind Reviewed

ISSN: 2319-7064

Downloads: 0

Student Project | Biological Sciences | India | Volume 11 Issue 5, May 2022

An Overview of Hepatitis B Virus Structure Pathology and Therapeutics

Debolina Banerjee

Abstract: The hepatitis B virus is a DNA virus belonging to the Hepadnaviridae family causing hepatitis B in humans. Hepatitis B is a viral infection that attacks the liver and can cause both acute and chronic disease. Treatment of Hepatitis B. The goal of treatment for chronic hepatitis B is to suppress HBV replication, prevent the progression of liver disease and thereby the development of cirrhosis, liver failure and HCC. Interferon alpha (?-IFN) is the first-line treatment option for patients without cirrhosis. Interferon has antiviral, anti-proliferative and immuno-modulatory effects. At a dose of 100 mg daily, lamivudine leads to a marked reduction or elimination of detectable HBV DNA in plasma in about 40% of HBeAg positive and 60-70% of HBeAg negative patients. Telbuvidine is a L-nucleoside analogue with potent anti-HBV activity. It is similar to lamivudine in mechanism of action and resistance profile but is more potent. However, its use is limited due to a high rate of resistance and cross-resistance with lamivudine. Emtricitabine is another L-nucleoside analogue with similar activity to that of lamivudine. Adefovir is a nucleotide analogue of deoxyadenosine monophosphate that has demonstrated efficacy in suppressing HBV DNA (20-50%) and normalizing liver function (50-70%). Entecavir is a carbocyclic analogue of 2' deoxyguanosine. It is a potent suppressor of HBV replication, resulting in loss of serum HBV DNA in 70-90%, and ALT normalization in 70-80% of patients. Tenofovir is a nucleotide analogue initially approved for the treatment of HIV. It is often used in a coformulation with emtricitabine. After 48 weeks of therapy with tenofovir, HBV DNA loss is achieved in 80-90% and ALT normalization in 70-80% of patients. Orthotopic liver transplantation is a treatment for chronic hepatitis B end-stage liver damage. However, the risk of reinfection on the graft is at least 80% with HBV presumably from extrahepatic reservoirs in the body.

Keywords: Hepatitis B, virus structure, mechanism, disease, DNA, virus cure

Edition: Volume 11 Issue 5, May 2022,

Pages: 977 - 981

How to Cite this Article?

Debolina Banerjee, "An Overview of Hepatitis B Virus Structure Pathology and Therapeutics", International Journal of Science and Research (IJSR), Volume 11 Issue 5, May 2022, pp. 977-981,

How to Share this Article?

Enter Your Email Address

Similar Articles with Keyword 'mechanism'

Downloads: 108

Review Papers, Biological Sciences, Mexico, Volume 6 Issue 9, September 2017

Pages: 1989 - 1997

A Review: Psychophysiology of Tool Use in Non-Human Primates

Manuel Alejandro Cruz-Aguilar [2] | Miguel Angel Guevara [2] | Marisela Hernandez-Gonzalez [2] | Ignacio Ramrez-Salado | Francisco Garcia-Orduna

Share this Article

Downloads: 108

Research Paper, Biological Sciences, India, Volume 7 Issue 7, July 2018

Pages: 1139 - 1144

Effects on the Selected Herbal Plant Syzygium Aromaticum Flower Buds Oil of Immunomodulatory Activity in Albino Wistar Rats

K. Umasankar | Balwin Nambikkairaj [3]

Share this Article