Research Paper | Medical Science | Saudi Arabia | Volume 11 Issue 3, March 2022
Association between Inflammatory Cytokines, and Growth Factors in Early Detection and Progression of Colorectal Cancer
Abstract: Background: Prevalence of colorectal cancers (CRC) is continuously elevating during the recent last decades. Objective: The main aim of this survey was to study the association between inflammatory cytokines, interleukins and growth factors in early detection and progression of colorectal cancer. Methodology: A total of 300 subjects (150diagnosed patients with CRC as cases + 150 healthy persons as controls) were included in this study. Growth factors and cytokines levels had been determined in all participated subjects' serum by using Luminex Technology Multiplex Assay (ELISA). A logistic regression analysis had been used for determining the association between CRC and plasma interleukins' levels after adjusting for some potential confounding factors. Results: 60% of the studied population were Saudis. Male?: ?female ratio was 8?: ?7. Subjects' age ranged from 45 to 86 years (mean ?SD: 64.4 ? 9.6). The mean body mass index (BMI) was 24.1?kg/m2 (?2.9). Significant differences were observed in the mean plasma levels between the CRC patients and controls for 13 plasma cytokines, namely IL-4, IL-8, IL-9, IL-17A, Eotaxin, G-CSF, IFN-?, TNF-?, IP-10, MIP-1?, MIP-1?, IFNG, and RANTES (p < 0.05). Conclusion: The significant elevation of serum inflammatory cytokines and growth factors in CRC patients suggesting the strong association and crucial role in early detection of CRC in humans.
Keywords: Inflammatory Cytokines, Growth Factors, Early Detection, Progression of Colorectal Cancer
Edition: Volume 11 Issue 3, March 2022,
Pages: 286 - 291
How to Cite this Article?
Mohammed Abdulrahman Alshahrani, "Association between Inflammatory Cytokines, and Growth Factors in Early Detection and Progression of Colorectal Cancer", International Journal of Science and Research (IJSR), Volume 11 Issue 3, March 2022, pp. 286-291, https://www.ijsr.net/get_abstract.php?paper_id=SR22304041346
How to Share this Article?
Similar Articles with Keyword 'Early Detection'
Bitot's Spots; Ocular Manifestation of Vitamin A Deficiency among School Children: A Case Report
Spectrum of Cervical Lesion in Papanicolaou Smears Examination in a Tertiary Care Hospital
Dr. Rakesh Shedge | Dr. Suhas Sonwane | Kalappa Dodake | Dr. Vikas Kavishwar | Dr. Mayura Phulpagar | Dr. Sweety Shinde | Dr. Kusum Jashnani