International Journal of Science and Research (IJSR)

International Journal of Science and Research (IJSR)
Call for Papers | Open Access | Double Blind Peer Reviewed

ISSN: 2319-7064




Downloads: 1 | Views: 14

Research Paper | Pathology | India | Volume 11 Issue 3, March 2022


To Study the Role of P53 and KI-67 in Differentiating Benign and Malignant Prostatic Lesions: A Study of 81 Cases at LLRM Medical College, Meerut

Dr. Nidhi Verma | Dr. Anshu Singh | Dr. Komal Saini


Abstract: Introduction: Immunohistochemistry can play an important rolein diagnostic surgical pathology and prognosis of prostatic lesions. Role of IHC markers p63, CKbE12 is well established and p53 and KI-67 are bring evaluated for their role as predictive or prognostic markers. Aims and objectives: To evaluate the immune-expression of p53 and ki-67 in benign and malignant prostatic lesions and their clinicopathological correlation. Material and methods: This study was done in LLRM Medical College attached to SVBP hospital Meerut, which included 81 patients with their detailed demographic data and clinical features of patients were studied with cystoscopic findings, serum Prostate specific antigen levels, histopathology and immunohistochemistry. Results: In our study, maximum cases were benign 52cases (64.2%), around 11cases (23.5%) were pre malignant and 18 cases (22.2%) were malignant. Stronger immune-positivity for p53 and Ki-67 was seen in higher grade of prostate cancer. Most common Gleason grade 2 (score 3+4) was seen in 08 cases (44.5%).


Keywords: P53, KI-67, Prostatic Lesion


Edition: Volume 11 Issue 3, March 2022,


Pages: 1104 - 1107


How to Download this Article?

Type Your Email Address below to Download the Article PDF


How to Cite this Article?

Dr. Nidhi Verma, Dr. Anshu Singh, Dr. Komal Saini, "To Study the Role of P53 and KI-67 in Differentiating Benign and Malignant Prostatic Lesions: A Study of 81 Cases at LLRM Medical College, Meerut", International Journal of Science and Research (IJSR), Volume 11 Issue 3, March 2022, pp. 1104-1107, https://www.ijsr.net/get_abstract.php?paper_id=SR22227121725



Similar Articles with Keyword 'P53'

Downloads: 0

Doctoral Thesis, Pathology, India, Volume 11 Issue 11, November 2022

Pages: 1480 - 1488

A Study of P53 Expression and its Correlation with Grades of Oral Squamous Cell Carcinoma

Dr. Ravina Yadav | Dr. Amrit Kalla

Share this Article

Downloads: 0

Research Paper, Pathology, India, Volume 12 Issue 1, January 2023

Pages: 495 - 498

Gliosarcoma: A Rare Variant of Glioblastoma Multiforme: Case Report

Dr. Nirali U Patel | Dr. Viral M Bhanvadia | Dr. Hansa Goswami [14]

Share this Article



Top