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Comparative Studies | Health and Medical Sciences | India | Volume 11 Issue 12, December 2022

Sexual Dysfunction with Olanzapine in Male and Female Patients of Schizophrenia

Dr. Malleeka Bora | Dr. Soumitra Ghosh

Abstract: Background: Since the launch of antipsychotic drugs, sexual side-effects have become one of the most important determinants of treatment compliance. Studies regarding sexual side-effects associated with antipsychotics comprise only a handful in the Indian population, especially so in this north-eastern part of the country. AIMS AND Objectives: 1) To assess the sexual dysfunction associated with olanzapine in male and female patient of Schizophrenia. 2) To compare the sexual dysfunction associated with olanzapine between male and female patients of Schizophrenia. Materials and Methods: This was a hospital based comparative study conducted on 50 clinically stable male and female patients of Schizophrenia on olanzapine only. A Sexual Functioning Questionnaire (SFQ) was administered after assessing the clinical stabilities with the Brief Psychiatric Rating Scale (BPRS). Sexual dysfunction was assessed by calculating the mean scores on all the domains of sexual functioning in SFQ which were then compared across the study groups using the Chi square test. The results were analysed using SPSS Version 16.0 setting the significance threshold at p <0.05. Results: When compared in male and female patients, Olanzapine was seen to cause more sexual desire disorders, more arousal disorders, more orgasmic difficulties and a more overall sexual dysfunction in males. In females, Olanzapine led to more sex-related pain disorders. Olanzapine induced sex-related pain disorders was found to be significant when compared between males and females (p=0.021). Conclusion: Sexual dysfunction can be caused by antipsychotic drugs. So clinicians should try to address these side-effects to help patients? attain a better compliance.

Keywords: Sexual dysfunction, Olanzapine, Schizophrenia

Edition: Volume 11 Issue 12, December 2022,

Pages: 370 - 374

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